The subject invention refers to the process of extracting phytochemicals and mixing of their active material composition from leaves, roots and fruits of several plants to formulate a cough syrup for the relief and treatment of mild & severe respiratory disorders brought about by bacteria and viruses, dust and pollens that may lead to difficulty in breathing resulting among others to coughs, allergies, colds, nasal congestions, pharyngitis, laryngitis, asthma and sneezing. The efficacy of the mixture of tropical plants having polyphenolic flavonoidal compounds derived from the basic below formula has yielded an effective remedy with little known side effects. I claim the formulations referred to as follows, but not limited thereto: Psidium guajava 25%, Zingiber officinale 30%, Curcuma longa 20%, Euphorbia hirta 10%, Adhatoda vasica 5%, and Citrofortunella microcarpa 3%.

The subject invention refers to the process of extracting phytochemicals and mixing of their active material composition from leaves, roots and fruits of several plants to formulate a cough syrup for the relief and treatment of mild & severe respiratory disorders brought about by bacteria and viruses, dust and pollens that may lead to difficulty in breathing resulting among others to coughs, allergies, colds, nasal congestions, pharyngitis, laryngitis, asthma and sneezing. The efficacy of the mixture of tropical plants having polyphenolic flavonoidal compounds derived from the basic below formula has yielded an effective remedy with little known side effects. I claim the formulations referred to as follows, but not limited thereto: Psidium guajava 25%, Zingiber officinale 30%, Curcuma longa 20%, Euphorbia hirta 10%, Adhatoda vasica 5%, and Citrofortunella microcarpa 3%.

The present invention discloses synergistic herbal compositions comprising a first ingredient Terminalia chebula extract containing metal salt or metal complex or metal chelate of at least one phytochemical in the extract selected from chebulagic acid, chebulinic acid, and gallic acid or mixtures thereof; and a second ingredient selected from extract(s), fraction(s), phytochemical(s) or mixtures thereof derived from Withania somnifera, Tinospora cordifolia and Andrographis paniculata; process for their preparation, methods of treatment and use of such compositions for improving immunity and respiratory health.

The present invention discloses synergistic herbal compositions comprising a first ingredient Terminalia chebula extract containing metal salt or metal complex or metal chelate of at least one phytochemical in the extract selected from chebulagic acid, chebulinic acid, and gallic acid or mixtures thereof; and a second ingredient selected from extract(s), fraction(s), phytochemical(s) or mixtures thereof derived from Withania somnifera, Tinospora cordifolia and Andrographis paniculata; process for their preparation, methods of treatment and use of such compositions for improving immunity and respiratory health.

The present invention discloses synergistic herbal compositions comprising a first ingredient Terminalia chebula extract containing metal salt or metal complex or metal chelate of at least one phytochemical in the extract selected from chebulagic acid, chebulinic acid, and gallic acid or mixtures thereof; and a second ingredient selected from extract(s), fraction(s), phytochemical(s) or mixtures thereof derived from Withania somnifera, Tinospora cordifolia and Andrographis paniculata; process for their preparation, methods of treatment and use of such compositions for improving immunity and respiratory health.

A bioactive formulation including ethanolic concentrates of Andrographolide extract in range of 90% by wt-99% by wt and aqueous 2 hydroxypropyl beta cyclodextrin in the range of 2% by wt-10% by wt. A method for preparation of the bioactive formulation including the following steps: mixing Andrographolide extract and ethanol to prepare ethanolic concentrates of Andrographolide (solvent A), mixing hydroxypropyl beta cyclodextrin and ethanol to obtain an ethanolic concentrate 2 hydroxypropyl beta cyclodextrin (Solvent B), mixing the solvent A and solvent B to obtain a complex concentrate solution, recovering ethanol solvent from the concentrate solution through distillation to obtain a thick paste of the concentrate, drying the paste at a temperature in the range of 55° C.-65° C. and pressure in the range of −650 to 700 mm Hg to obtain a dried complex concentrate followed by converting into an amorphous powder to obtain a bioactive formulation.

A bioactive formulation including ethanolic concentrates of Andrographolide extract in range of 90% by wt-99% by wt and aqueous 2 hydroxypropyl beta cyclodextrin in the range of 2% by wt-10% by wt. A method for preparation of the bioactive formulation including the following steps: mixing Andrographolide extract and ethanol to prepare ethanolic concentrates of Andrographolide (solvent A), mixing hydroxypropyl beta cyclodextrin and ethanol to obtain an ethanolic concentrate 2 hydroxypropyl beta cyclodextrin (Solvent B), mixing the solvent A and solvent B to obtain a complex concentrate solution, recovering ethanol solvent from the concentrate solution through distillation to obtain a thick paste of the concentrate, drying the paste at a temperature in the range of 55° C.-65° C. and pressure in the range of −650 to 700 mm Hg to obtain a dried complex concentrate followed by converting into an amorphous powder to obtain a bioactive formulation.

A bioactive formulation including ethanolic concentrates of Andrographolide extract in range of 90% by wt-99% by wt and aqueous 2 hydroxypropyl beta cyclodextrin in the range of 2% by wt-10% by wt. A method for preparation of the bioactive formulation including the following steps: mixing Andrographolide extract and ethanol to prepare ethanolic concentrates of Andrographolide (solvent A), mixing hydroxypropyl beta cyclodextrin and ethanol to obtain an ethanolic concentrate 2 hydroxypropyl beta cyclodextrin (Solvent B), mixing the solvent A and solvent B to obtain a complex concentrate solution, recovering ethanol solvent from the concentrate solution through distillation to obtain a thick paste of the concentrate, drying the paste at a temperature in the range of 55° C.-65° C. and pressure in the range of −650 to 700 mm Hg to obtain a dried complex concentrate followed by converting into an amorphous powder to obtain a bioactive formulation.

Medicinal plant extracts and their bioactives from Alpinia, Magnolia, Kochia and Piper/Pepper are disclosed herein in combination or alone in regulating homeostasis of chondrocytes, extracellular matrix, articular cartilage, and phenotype of arthritis that lead to enhanced anabolic functions of chondrocytes, increased renewal/rebuilding/regeneration of extracellular matrix and articular cartilage, and improved phenotype of osteoarthritis and rheumatoid arthritis.

Medicinal plant extracts and their bioactives from Alpinia, Magnolia, Kochia and Piper/Pepper are disclosed herein in combination or alone in regulating homeostasis of chondrocytes, extracellular matrix, articular cartilage, and phenotype of arthritis that lead to enhanced anabolic functions of chondrocytes, increased renewal/rebuilding/regeneration of extracellular matrix and articular cartilage, and improved phenotype of osteoarthritis and rheumatoid arthritis.