A converter module is described which handles memory requests issued by a cache (e.g. an on-chip cache), where these memory requests include memory addresses defined within a virtual memory space. The converter module receives these requests, issues each request with a transaction identifier and uses that identifier to track the status of the memory request. The converter module sends requests for address translation to a memory management unit and where there the translation is not available in the memory management unit receives further memory requests from the memory management unit. The memory requests are issued to a memory via a bus and the transaction identifier for a request is freed once the response has been received from the memory. When issuing memory requests onto the bus, memory requests received from the memory management unit may be prioritized over those received from the cache.

Provided are a non-volatile dual inline memory module (NVDIMM) supporting a DRAM cache mode and an operation method of the NVDIMM. The NVDIMM includes a DRAM chip, an NVM chip, and a controller that controls the DRAM chip to operate as a cache memory of the NVM chip. The controller sends a read command to the DRAM chip with reference to a cache address of data requested to be written from a host to the NVM chip, and sends a write command to the NVM chip with reference to an address of the data requested to be written at a time point when a read latency (RL) of the DRAM chip and a write latency (WL) of the NVM chip coincide with each other.

Provided are a non-volatile dual inline memory module (NVDIMM) supporting a DRAM cache mode and an operation method of the NVDIMM. The NVDIMM includes a DRAM chip, an NVM chip, and a controller that controls the DRAM chip to operate as a cache memory of the NVM chip. The controller sends a read command to the DRAM chip with reference to a cache address of data requested to be written from a host to the NVM chip, and sends a write command to the NVM chip with reference to an address of the data requested to be written at a time point when a read latency (RL) of the DRAM chip and a write latency (WL) of the NVM chip coincide with each other.

A processing unit includes a processor core and an associated cache memory. The cache memory establishes a reservation of a hardware thread of the processor core for a store target address and services a store-conditional request of the processor core by conditionally updating the shared memory with store data based on the whether the hardware thread has a reservation for the store target address. The cache memory receives a hint associated with the store-conditional request indicating an intent of the store-conditional request. The cache memory protects the store target address against access by any conflicting memory access request during a protection window extension following servicing of the store-conditional request. The cache memory establishes a first duration for the protection window extension based on the hint having a first value and establishes a different second duration for the protection window extension based on the hint having a different second value.

A system for tracking memory access patterns to be used in making data placement and migration policies. The system includes a processing unit and a system memory. The system memory includes a local memory and a remote memory, each of which having mapped thereon, a plurality of memory pages. Each of the plurality of memory pages corresponds to one or more physical addresses. A set of attributes for each memory page is stored in a physical attribute table (PAT). The PAT is looked up and the attributes updated when a memory access is detected. Attributes stored in the PAT are used to control the movement of memory pages between the local memory and the remote memory. When the attributes in the PAT indicate a remote memory page is being accessed frequently by the processing unit, the remote memory page is moved from the remote memory to the local memory.

Operating system deactivation of write protection for a storage block is provided absent quiescing of processors in a multi-processor computing environment. The process includes receiving an address translation protection exception interrupt resulting from an attempted write access by a processor to a storage block, and determining by the operating system whether write protection for the storage block is active. Based on write protection for the storage block not being active, the operating system issues an instruction to clear or modify translation lookaside buffer entries of the processor associated with the storage block, absent waiting for an action by another processor of multiple processors of the computing environment, to facilitate write access to the storage block proceeding at the processor.

An apparatus comprises an interconnect providing communication paths between agents coupled to the interconnect. A coordination agent is provided which performs an operation requiring sending a request to each of a plurality of target agents, and receiving a response from each of the target agents, the operation being unable to complete until the response has been received from each of the target agents. Storage circuitry is provided which is accessible to the coordination agent and configured to store, for each agent that the coordination agent may communicate with via the interconnect, a latency indication for communication between that agent and the coordination agent. The coordination agent is configured, prior to performing the operation, to determine a sending order in which to send the request to each of the target agents, the sending order being determined in dependence on the latency indication for each of the target agents.

Methods and apparatus implementing Hardware/Software co-optimization to improve performance and energy for inter-VM communication for NFVs and other producer-consumer workloads. The apparatus include multi-core processors with multi-level cache hierarchies including and L1 and L2 cache for each core and a shared last-level cache (LLC). One or more machine-level instructions are provided for proactively demoting cachelines from lower cache levels to higher cache levels, including demoting cachelines from L1/L2 caches to an LLC. Techniques are also provided for implementing hardware/software co-optimization in multi-socket NUMA architecture system, wherein cachelines may be selectively demoted and pushed to an LLC in a remote socket. In addition, techniques are disclosure for implementing early snooping in multi-socket systems to reduce latency when accessing cachelines on remote sockets.

A system includes a memory including a plurality of rings, an endpoint associated with a ring of the plurality of rings, and a gateway. The gateway is configured to receive a notification from the endpoint regarding a packet made available in the ring associated with the endpoint, access the ring with an RDMA read request, retrieve the packet made available in the ring, and forward the packet on an external network.

The present invention relates to a bioactive agent capable of increasing the intracellular concentration and/or activity of Hsp70 for use in the treatment of a lysosomal storage disease which arise from a defect in an enzyme whose activity is not directly associated with the presence of lysosomal BMP as a co-factor; such as glycogen storage diseases, gangliosidoses, neuronal ceroid lipofuscinoses, cerebrotendinous cholesterosis, Wolman's disease, cholesteryl ester storage disease, disorders of glycosaminoglycan metabolism, mucopolysaccharidoses, disorders of glycoprotein metabolism, mucolipidoses, aspartylglucosaminuria, fucosidosis, mannosidoses, and sialidosis type II.