The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

The present invention is a mass spectrometer (1) for sequentially performing a measurement for a plurality of target ions, characterized by a storage section (41) for holding ion time-of-flight information concerning the time required for each of target ions to fly through each of the sections constituting the mass spectrometer, and a voltage controller (42) for changing, based on the ion time-of-flight information, the voltage applied to each of those sections to a voltage suited for each target ion, with a time lag corresponding to the difference in the timing of the arrival of the target ion at the section concerned.

Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.

An excessive overshoot preventing unit (16) is connected to a loop in which a command voltage Vf according to a difference between: a voltage obtained by dividing an output voltage Vout as a high voltage; and a control voltage V cont set from the outside is obtained and fed back to each of drive circuits (3 and 5) of a positive voltage generating unit (2) and a negative voltage generating unit (4). The excessive overshoot preventing unit (16) clamps the command voltage Vf at a voltage value according to the control voltage Vcont. An overshoot that occurs in the voltage generating unit (2 or 4) at the time of polarity switching mainly depends on a circuit constant, and hence the amount of overshoot is excessive in the case of a low-voltage output even if the amount of overshoot is optimal in the case of a rated output. To deal with this, in this power unit, the overshoot of the command voltage Vf in suppressed by the excessive overshoot preventing unit (16), and hence the output voltage can be promptly settled to a target voltage even in the case of a low-voltage output.

A system for detecting particles in a gas stream comprises a Faraday collector separating charged particles into positive and negative streams to be detected. The Faraday collector includes a plurality of interdigitated wires, with a first plurality of wires charged with a positive potential and a second plurality of wires charged with a negative potential to separate particles in the gas stream into the positive and negative streams.

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

The present disclosure provides an integrated device for rapid pretreatment-ionization-detection comprising: (a) a fixing device for fixing a sample to be treated; b) a rapid pretreatment-ionization device comprising: a voltage output module for generating an AC voltage; a boost module for boosting and amplifying the voltage to achieve an adjustable pulse voltage of 1 mV-100 kV; a delay module for setting a delay time for the voltage output; and a trigger module for receiving a pulse voltage trigger; (c) a mass spectrometer; and (d) a timing control device for controlling the mass spectrometer and the rapid pretreatment-ionization device to collect a signal. According to the integrated device, mutual separation between analytes in a cell sample and separation between an analyte and a complex matrix can be achieved, and the separation time can reach a sub-millisecond level.

A method of ion detection comprises: (a) setting electrical potentials of a dynode and a scintillator electrode of a Daly detector and of a focusing lens disposed at an ion inlet of the Daly detector so as to detect negatively charged ions received from a mass analyzer or mass filter; (b) transferring the negatively charged ions from the mass analyzer or mass filter to the Daly detector through the lens and detecting said negatively charged ions by a photodetector of the Daly detector; (c) setting electrical potentials of the dynode, the scintillator electrode and the focusing lens of the Daly detector so as to detect positively charged ions received from the mass analyzer or mass filter; and (d) transferring the positively charged ions from the mass analyzer or mass filter to the Daly detector through the lens and detecting said positively charged ions by the photodetector.

The present disclosure of the invention concerns embodiments directed to a multi-pressure chemical ionization multi-ion identification device (MPCI MION device), a system and method using the same to utilize chemical ionization (CI) in multiple adduct formation from the substances in the sampled gas of a gas sample being addressed to be analyzed in a mass analyzer. The multi-pressure multi-ion identification (MPCI MION) device comprises a buffering region to have the sample flow turbulence decayed before the sample flow entrance to the low pressure ionization regions (IR(A)), IR(B), (IR(B), (IR(C), IR(D)) (IR(E)) utilizing chemical ionization by reagents from an ensemble of reagent ion towers (R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18,).

A hybrid inductively coupled plasma mass spectrometer (ICP-MS) system is disclosed for simultaneous elemental and molecular analysis in positive and negative polarities. It includes an ICP torch that generates plasma with a buffer gas, producing both positively and negatively charged ions from a sample. Positioned between the sampler and skimmer, an insert with a defined geometry forms a reaction chamber. Various embodiments feature multiple apertures for pressure control, a rotatable disk for aperture regulation, a slider gate for pressure adjustment, a circular gate with adjustable radial apertures, and an inlet for introducing gases, reagents, dopants, or analytes. These components enable precise pressure modulation, optimizing performance for dual-polarity mass spectrometry. The system enhances analytical flexibility by facilitating controlled ion reactions, improving sensitivity and specificity for both elemental and molecular applications. This innovation expands ICP-MS functionality, supporting diverse scientific and industrial applications requiring high-precision mass analysis.