Apparatus and methods for imaging and tracking of nano- and micro-scale objects with acceptable latency for relevant medical procedures, such as delivery of therapeutic payload or minimally invasive surgery are disclosed, including the capability to superimpose accurate anatomical data over a tracking image. Software applications are provided for data logging via a remote-control station; and software interface with remote motion control mechanism, controlling the motion of internal device.

A significant enhancement of detection capabilities of the room temperature MPQ is seen using optical lithography-defined, ferromagnetic iron-nickel alloy microdisks. Irreversible transitions between strongly non-collinear (vortex) and a collinear single domain states, driven by an ac magnetic field, translate into a nonlinear magnetic response that enables ultrasensitive detection of material at relatively small magnetic fields.

The present invention relates to a magnetic resonance imaging (MRI) contrast agent, particularly an MRI contrast agent derived from nanoparticle that is porous first metal-doped second metal oxide nanoparticle with a central cavity, and a method for producing the same. The MEI contrast agent made in accordance with the present invention can be used not only as a drug-delivery agent for therapy but also as an MRI contrast agent for diagnosis.

The present invention relates to a magnetic resonance imaging (MRI) contrast agent, particularly a metal oxide nanoparticle-based T1-T2 dual-mode MRI contrast agent that can be used not only as a T1 MRI contrast agent but also as a T2 MRI contrast agent, and a method for producing the same. The metal oxide nanoparticle-based T1-T2 dual-mode MRI contrast agent can provide more accurate and detailed information associated with disease than single MRI contrast agent by the beneficial contrast effects in both T1 imaging with high tissue resolution and T2 imaging with high feasibility on detection of a lesion.

Multifunctional nanoparticles can include two or more different populations of nanocrystals that impart a combination of properties arising from the constituent populations in a single, multifunctional nanoparticle.

The present invention addresses the problem of providing: a hydrogel particle which can be taken into a cell by the action of the cell and can control the release of a magnetic particle enclosed therein into the cell so as to retain the magnetic particle in the cell for a long period; a method for producing the hydrogel particle; a cell or a cell structure each enclosing the hydrogel particle therein; and a method for evaluating the activity of a cell using the hydrogel particle. The present invention solves the problem by a hydrogel particle including: a domain which is composed of a first hydrogel; a matrix which encloses the domain and is composed of a second hydrogel having a different crosslinking degree or composition from that of the first hydrogel; and a magnetic particle which is supported by at least the first hydrogel.

A composite implant for providing simultaneous magnetic resonance imaging (MRI) and computed tomographic (CT) imaging contrast is disclosed. The composite implant is formed of a calcium compound in the form of nano or microparticles doped with a first dopant configured to provide MRI contrast and a second dopant configured to provide CT contrast. The calcium compound is loaded onto a polymer gel matrix and lyophilized to form a mass with 3-dimensionally interconnected porosity, configured to provide tissue integration and proliferation sites. Methods of forming the composite implant are also disclosed. The implant could be a scaffold or bead structured to enable treatment of human or animal patient for bone/cartilage injury or defect by implantation, with MRI and CT monitoring.

Provided is a fluoride nanophosphor using, as cores, luminescent nanoparticles expressed by Chemical Formula 1.

LiEr.sub.1-x-yL.sub.yF.sub.4:Tm.sup.3+.sub.x[Chemical Formula 1]

(In Chemical Formula 1, x is a real number satisfying 0x0.3, y is a real number satisfying 0y0.8 and is selected within a range satisfying 0x+y0.9, and L is any one selected from the group consisting of yttrium (Y), lanthanum (La), cerium (Ce), praseodymium (Pr), neodymium (Nd), promethium (Pm), samarium (Sm), europium (Eu), gadolinium (Gd), terbium (Tb), dysprosium (Dy), holmium (Ho), ytterbium (Yb), lutetium (Lu), and a combination thereof.)

The disclosure pertains to conformational epitopes in A-beta, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.