Certain embodiments are directed to Lipid Emulsions in Alginate Microspheres, e.g., Lipiodol Emulsion in Alginate Microspheres (LEAMs), as a chemoembolic agent. A oil in water emulsion of lipiodol can be stabilized within alginate microspheres at very high concentrations. These emulsion in alginate microspheres can be manufactured to any size range from 20 microns to 5000 microns. In certain aspects, an ultrasonic nozzle technology is used to manufacture small size microspheres of average diameter 50 microns. In other aspects, needle extrusion systems are used to manufacture large LEAMs termed Mega-LEAMs.