Provided are methods for preparing pathogen-inactivated platelet compositions, as well as processing sets and compositions related thereto.

A device for feeding a line through the skin of a patient, wherein the line contains a photodynamic substance that releases highly reactive oxygen derivatives when irradiated. Thus, disinfection/sterilization can be achieved in the region of a feed-through both on the outside of the skin and in the feed-through region by irradiating the feed-through.

The invention relates to a recipient (1) for ex-vivo treatment of biological liquids, which includes: a rigid body (2); a reservoir (3) provided inside the body (2), which is formed by a side wall (4), a rigid upper wall (5) and a rigid lower wall (6) and has an internal thickness defined by the separation between the upper wall (5) and the lower wall (6), at least one of the upper wall (5) or the lower wall (6) having a window area (7) configured to allow the passage of electromagnetic radiation from outside of the body (2) to the reservoir (3); two ports (8, 9) for liquids to gain access to the reservoir (3) from outside of the body (2); and closure means (10, 11) for the ports (8, 9), the closure means (10, 11) being configured to provide, jointly, the reservoir (3) with hermetic sealing against gases and liquids.

An applicator in the form of a container or cannister that is arranged to apply one or more photosensitizers to surfaces. The applicator includes at least one light source and the one or more photosensitizers. Light combined with the photosensitizers creates singlet oxygen and other radical species which are toxic to viruses and other pathogens. The photosensitizers may be combined in a powder form, or in an aqueous solution. Any light source can be used that emits the proper wavebands or wavelengths of light that are effectively absorbed by the photosensitizers leading to singlet oxygen generation.

An evaluation device includes: a processing container that has an intake port and an exhaust port; a microorganism supply device that floats microorganisms in the air inside the processing container; a light source that irradiates the microorganisms floating in the air inside the processing container with ultraviolet rays while the intake port and the exhaust port are in a state of being closed; and a microorganism recovery device that is connected to the exhaust port. The microorganism recovery device discharges air that has a volume larger than the capacity of the inside of the processing container through the exhaust port while introducing air that does not contain microorganisms to be evaluated into the inside of the processing container through the intake port after the irradiation with the ultraviolet rays and recovers the microorganisms contained in the air that is discharged.

An implantable article comprising a dissolvable sponge derived from the mixture of chitosan, a first polysaccharide and a second polysaccharides. The polysaccharides have different number average molecular weight characteristics to enable the control of the mechanical features of the sponge.

Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

The arrangement for the contamination-free introduction of a sterile object (3) from a vessel (2), which has been closed by means of a semipermeable cover (23), into a working chamber (90), which is surrounded by a wall (91), of a containment (9) firstly comprises a portal unit (7) having an access flange (71) which is arranged in the wall (91) and which forms a passage (75) from the outside into the working chamber (90), and a door (5) which sealingly closes the passage (75) and which, in order to be opened, can be moved into the working chamber (90). The arrangement furthermore comprises a vessel receptacle (6) having a repository (60) for holding a vessel (2) that has been introduced into the vessel receptacle (6), an opening for the introduction of the vessel (2) into the repository (60), and a flange (61) for interacting with the access flange (71). The arrangement furthermore includes a decontamination unit (4) which is designed to, when the door (5) has been closed, the vessel receptacle (6) has been docked to the access flange (71) and the vessel (2) has been stored in the vessel receptacle (6), decontaminate an outer surface, facing toward the door (5), of the cover (23). Based on this arrangement, a method for introduction is also disclosed.

A device for treating a surface with a dielectric harrier plasma, wherein the surface functions as a counterelectrode, has an electrically insulating housing and a housing head. A rotatable electrode connected to a high-voltage feed line is shielded by a dielectric and protrudes out of the housing head. The configuration has fundamentally unrestricted movement of the electrode over the surface to be treated in that the electrode has rotary bearing elements which are arranged in a center axis and a rotation axis is at an angle to the center axis.

An implantable article comprising a dissolvable sponge derived from the mixture of chitosan, a first polysaccharide and a second polysaccharides. The polysaccharides have different number average molecular weight characteristics to enable the control of the mechanical features of the sponge.