An absorbent composition containing cellulose nanofibers and a cellulose derivative and a method for making the same are disclosed. The cellulose derivative has a viscosity of 1000 mPa.Math.s or higher in a 1 mass % aqueous solution at 25° C. and a degree of etherification of less than 0.9. The cellulose derivative is preferably at least one member selected from the group consisting of carboxymethyl cellulose, carboxyethyl cellulose, a carboxymethyl cellulose salt, and a carboxyethyl cellulose salt, more preferably a carboxymethyl cellulose salt, even more preferably sodium carboxymethyl cellulose.

An absorbent composition containing cellulose nanofibers and a cellulose derivative and a method for making the same are disclosed. The cellulose derivative has a viscosity of 1000 mPa.Math.s or higher in a 1 mass % aqueous solution at 25° C. and a degree of etherification of less than 0.9. The cellulose derivative is preferably at least one member selected from the group consisting of carboxymethyl cellulose, carboxyethyl cellulose, a carboxymethyl cellulose salt, and a carboxyethyl cellulose salt, more preferably a carboxymethyl cellulose salt, even more preferably sodium carboxymethyl cellulose.

A method and system of using a polyolefin-based, hot melt adhesive improves creep performance of elastic strands adhered to another substrate. Some deflection, greater than 1°, of the exit angle formed by a line normal to the axis of a neutrally-positioned applicator and the elastic strand extending from the applicator is introduced. Preferably, deflection of the entrance angle is also introduced and a head tilt angle is also provided. The use of deflection improves creep performance or allows for a reduced amount of adhesive to be used to achieve the same or similar creep performance. The elastic strands may be used to form a leg cuff in personal care products, such as diapers, and the substrate to which they are applied could be a polyethylene film or non-woven materials.

A dressing that includes an absorbent, antimicrobial layer and a bioresorbable layer is disclosed herein. The absorbent, antimicrobial layer may be formed from nonwoven fibers. The bioresorbable layer may include an extracellular polymeric substance-active agent, such as citric acid. At least a portion of the nonwoven fibers may include carboxymethylcellulose fibers and alginate fibers.

An absorbent article comprising an absorbent core sandwiched between a liquid permeable topsheet and a liquid impermeable backsheet, and an acquisition distribution layer positioned between said topsheet and said absorbent core, wherein the absorbent core comprises absorbent material selected from the group consisting of cellulose fibers, superabsorbent polymers and combinations thereof, wherein said absorbent core comprises at least one core wrap substrate enclosing said absorbent material, and wherein a top layer of said core wrap is adhered to a bottom layer of said core wrap to form one or more channels substantially free of said absorbent material, wherein said channels have a length extending along a longitudinal axis and the absorbent core has a length extending along said longitudinal axis and wherein the length of said channels is from 10% to 95% of the length of said absorbent core and wherein said channels each follow a substantially continuous path such as from a first end of a channel to a second end of the same channel wherein the acquisition distribution layer comprises a spunbond and/or carded nonwoven layer comprising synthetic fibers, wherein said synthetic fibers are comprised at a level of greater than 80% wt by weight of said acquisition distribution layer, and wherein said acquisition distribution layer has a basis weight of from 10 to 50 g/m.sup.2.

Described herein are biocompatible materials that include a nitric oxide (NO) donor embedded in silk fibroin nanoparticles. In one aspect, the nitric oxide donor is present in the hydrophobic core of the silk fibroin nanoparticles such that the nitric oxide donor is encapsulated. The biocompatible materials described herein serve as a biocompatible and inexpensive nitric oxide delivery platform that provide sustained release of nitric oxide. The biocompatible materials are non-toxic and can be used in biomedical applications such as wound healing, where a combination of therapeutic and antibacterial properties of silk and nitric oxide are desired. Additionally, described herein are methods of making the biocompatible materials.

Described herein are biocompatible materials that include a nitric oxide (NO) donor embedded in silk fibroin nanoparticles. In one aspect, the nitric oxide donor is present in the hydrophobic core of the silk fibroin nanoparticles such that the nitric oxide donor is encapsulated. The biocompatible materials described herein serve as a biocompatible and inexpensive nitric oxide delivery platform that provide sustained release of nitric oxide. The biocompatible materials are non-toxic and can be used in biomedical applications such as wound healing, where a combination of therapeutic and antibacterial properties of silk and nitric oxide are desired. Additionally, described herein are methods of making the biocompatible materials.

The invention relates to a biocompatible, flexible, haemostatic sheet comprising: a cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space; and distributed within the interstitial space, a plurality of reactive polymer particles comprising (i) a water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups in tissue and blood under the formation of a covalent bond and (ii) a nucleophilic cross-linking agent that contains at least two reactive nucleophilic groups that are capable of reacting with the reactive electrophilic groups of the electrophilic polymer under the formation of a covalent bond, said reactive polymer particles having a diameter in the range of 0.5-100 μm and being present in an amount of at least 3% by weight of the fibrous carrier structure.

When blood is absorbed by the haemostatic sheet of the present invention, the water-soluble electrophilic polymer in the reactive polymer particles starts dissolving as soon as these particles are ‘wetted’ by the blood, thereby allowing the electrophilic polymer to react with reactive nucleophilic groups in the blood and tissue, as well as with reactive nucleophilic groups of the nucleophilic cross-linking agent, thereby inducing blood coagulation and tissue sealing, both of which contribute to haemostasis.

The invention relates to a biocompatible, flexible, haemostatic sheet comprising: a cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space; and distributed within the interstitial space, a plurality of reactive polymer particles comprising (i) a water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups in tissue and blood under the formation of a covalent bond and (ii) a nucleophilic cross-linking agent that contains at least two reactive nucleophilic groups that are capable of reacting with the reactive electrophilic groups of the electrophilic polymer under the formation of a covalent bond, said reactive polymer particles having a diameter in the range of 0.5-100 μm and being present in an amount of at least 3% by weight of the fibrous carrier structure.

When blood is absorbed by the haemostatic sheet of the present invention, the water-soluble electrophilic polymer in the reactive polymer particles starts dissolving as soon as these particles are ‘wetted’ by the blood, thereby allowing the electrophilic polymer to react with reactive nucleophilic groups in the blood and tissue, as well as with reactive nucleophilic groups of the nucleophilic cross-linking agent, thereby inducing blood coagulation and tissue sealing, both of which contribute to haemostasis.

The present invention relates to a haemostatic powder comprising at least 10 wt. % of particle agglomerates, said particle agglomerates having a diameter in the range of 1-500 μm and comprising: electrophilic polyoxazoline particles containing electrophilic polyoxazoline carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups in blood under the formation of a covalent bond; and nucleophilic polymer particles containing a water-soluble nucleophilic polymer carrying at least 3 reactive nucleophilic groups that, in the presence of water, are capable of reacting with the reactive electrophilic groups of the electrophilic polyoxazoline under the formation of a covalent bond between the electrophilic polyoxazoline and the nucleophilic polymer.

When applied to a bleeding site, the haemostatic powder of the present invention turns into a gel while at the same time binding to proteins present in the blood and on the surrounding tissue.