The present disclosure provides an anti-infective and anti-adhesive wound dressing based on nonspecific adhesion to bacteria, which includes a micron-sized porous membrane with polyolefin contained in its surface and does not contain any bactericide. According to the disclosure, through targeted selection of a material and surface structure of the porous membrane, nonspecific adhesion to the bacteria on the wound surface can be formed by good adaptability of its own surface energy and the structure of the porous membrane to surface energy of the bacteria, preventing the bacteria from penetrating into wound tissues and thus realizing the anti-infection for the bacteria and the anti-adhesion to the wound. Furthermore, no bactericide is required to be added, which not only reduces infection of the wound, but also weakens factors which are not conducive to wound healing, such as aggravation of inflammation caused by bacterial toxin released after bacterial rupture in traditional sterilization mechanisms.

The invention is related to the nanofibrous wound dressing that has been developed to be used in the treatment of various types of skin wounds including chronic and acute wounds in the biomedical sector, wherein said wound dressing comprises a bioactive agent that promotes the process of wound healing.

This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.

The present invention provides a modified collagen comprising S-nitroso groups and a method of manufacture of such a modified collagen. Also provided is a wound dressing comprising such a modified collagen, particularly a wound dressing comprising a formulated composition comprising such a modified collagen.

The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

Devices for delivering a flowable tissue dressing material for treating a tissue site are described. The devices include a first zone including a first reactant, such as a polyol, and a second zone including a second reactant, such as a multi-isocyanate, which can be mixed together to form a flowable tissue dressing material. The device can also include a flowable tissue dressing material including a reacted polymer present in a carrier. Kits and methods including and/or using the devices are also described.

Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.

The invention concerns a composition to be electrospun comprising a first compound to be electrospun, an electrospinning promoter and at least one active ingredient, as well as a method to prepare it. This composition allows to obtain electrospun nanometric fibers with good structural and absorption properties.

The present invention provides a hemostatic porous composite sponge comprising: i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

A method for making an absorbent article comprising an absorbent core comprising one or more channels, the method comprising the steps of: i. providing a first endless moving surface comprising a plurality of molds typically in the form of pockets, each mold comprising an insert therein, wherein the molds are in fluid communication with an under-pressure source except for said insert such that a suction zone is formed in areas neighboring said insert; ii. feeding a first nonwoven web to said first endless moving surface and over one or more said molds; iii. depositing an absorbent material, comprising cellulose fibers and/or superabsorbent polymer particles, over at least a portion of said nonwoven web; iv. optionally further selectively removing said absorbent material from areas of the nonwoven web corresponding to said insert; v. applying a second nonwoven web directly or indirectly over the absorbent material, or folding said first nonwoven web, such to sandwich said absorbent material between upper and lower layers of said nonwoven web(s); vi. joining said upper and lower layers together at least in the areas of the nonwoven web(s) corresponding to the insert to form an absorbent core having one or more channels substantially free of absorbent material; vii. optionally joining an acquisition distribution layer to said absorbent core, typically a skin facing surface of said upper layer; viii. optionally laminating said absorbent core and acquisition distribution layer between a liquid pervious topsheet and a liquid impervious backsheet; wherein at least a portion of said insert is porous and is in fluid communication with a positive pressure source such that air is blown out of said insert to form an air cushion or air film around at least an uppermost surface of said insert and in that said absorbent material is thereby forced away from areas of the nonwoven web corresponding to said insert.