The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

Wound care coverings include a pad comprising a pad material, a lactate-based enzyme crosslinked with the pad material by a crosslinker, and a dye that changes color when H.sub.2O.sub.2 is present. In examples, an enzyme layer comprises a pad material crosslinked with a sugar-based enzyme by a crosslinker, a sugar-containing layer comprises a sugar in a hydrogel, and a rupturable barrier is between the enzyme layer and sugar-containing layer. In examples, a first enzyme layer comprises a first pad material, a lactate-based enzyme and a dye that changes color when H.sub.2O.sub.2 is present; a second enzyme layer comprises a second pad material crosslinked with a sugar-based enzyme by a second crosslinker; a sugar-containing layer comprises a sugar in a hydrogel, where the second enzyme layer is between the sugar-containing layer and the first enzyme layer; and a rupturable barrier is between the second enzyme layer and the sugar-containing layer.

Wound care coverings include a pad comprising a pad material, a lactate-based enzyme crosslinked with the pad material by a crosslinker, and a dye that changes color when H.sub.2O.sub.2 is present. In examples, an enzyme layer comprises a pad material crosslinked with a sugar-based enzyme by a crosslinker, a sugar-containing layer comprises a sugar in a hydrogel, and a rupturable barrier is between the enzyme layer and sugar-containing layer. In examples, a first enzyme layer comprises a first pad material, a lactate-based enzyme and a dye that changes color when H.sub.2O.sub.2 is present; a second enzyme layer comprises a second pad material crosslinked with a sugar-based enzyme by a second crosslinker; a sugar-containing layer comprises a sugar in a hydrogel, where the second enzyme layer is between the sugar-containing layer and the first enzyme layer; and a rupturable barrier is between the second enzyme layer and the sugar-containing layer.

A composition including a solution at least one acrylic adhesive and particles of a cross-linked polymer having a carboxylate-group density between 2.0 and 12.0 meq/g and an average pore size between 0.005 and 1.0 μm, usable in particular for creating an adhesive matrix suitable for any device, for example for medical aims such as a patch, a film, a strip or a dressing, preferably a dressing, or suitable for any device of the functional textile type such as a sports item.

A composition including a solution at least one acrylic adhesive and particles of a cross-linked polymer having a carboxylate-group density between 2.0 and 12.0 meq/g and an average pore size between 0.005 and 1.0 μm, usable in particular for creating an adhesive matrix suitable for any device, for example for medical aims such as a patch, a film, a strip or a dressing, preferably a dressing, or suitable for any device of the functional textile type such as a sports item.

A nanofibrous mat comprising: electrospun nanofibres forming said mat; and ceramic particles dispersed throughout said nanofibres and comprising a ceramic matrix and a dopant releasably encapsulated within said ceramic matrix, wherein the ceramic particles are dispersed throughout the nanofibres during electrospinning of the nanofibres, whereby said dopant is protected by said ceramic matrix during said electrospinning.

Disclosed are methods of promoting wound healing in a patient in need thereof comprising administering to the patient a composition comprising a neonatal fibrin scaffold. Further disclosed are in vitro methods for evaluating a target composition on human wound healing comprising a neonatal porcine plasma scaffold with the target composition and evaluating scaffold properties of the plasma sample.

This invention relates to a polymer composition containing at least one polymer and at least one agent, formed bodies having such a polymer composition, the use of the formed bodies and polymer compositions, and corresponding threads, nonwoven materials, clothing articles, and medical aids.

This invention relates to a polymer composition containing at least one polymer and at least one agent, formed bodies having such a polymer composition, the use of the formed bodies and polymer compositions, and corresponding threads, nonwoven materials, clothing articles, and medical aids.

The present invention has absorbency for the exudate of the wound surface and can maintain a moist environment suitable for promoting healing of the wound surface for a long time, an adhesive transparent multi-functional wound-covering material and a method for manufacturing the same are proposed so as not to cause pain or damage to the regenerated skin when replacing the wound dressing. Such a wound-covering material includes 14% by weight of polyvinylpyrrolidone, 5% by weight of propylene glycol, 79.0996% by weight of water, 0.6% by weight of calcium chloride, 0.3% by weight of potassium sorbate, 0.0004% by weight of RH oligopeptide, and 1% by weight of D-xylitol.