An object of the invention is to provide an eco-friendly adhesive which is eco-friendly and economical using lignin hydrogel. In order to achieve the above-identified object, in an eco-friendly adhesive including lignin hydrogel according to the invention, the lignin hydrogel includes a network structure through a bonding between lignin and a zwitterionic polymer.

The invention provides a method for preparing tissue-adhesive sheets that may suitably be applied as an implantable haemostatic or sealing construct during surgical procedures, said method comprising: providing a fibrous sheet comprising a three-dimensional interconnected interstitial space; providing reactive polymer particles comprising a water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups in blood under the formation of a covalent bond; placing the fibrous sheet and the reactive polymer particles between two electrodes; simultaneously subjecting the fibrous sheet and the reactive polymer particles to an electric field of 0.1 to 40 kV/mm to impregnate the interconnected interstitial space of the fibrous sheet with the reactive polymer particles.

The present invention provides a hemostatic porous composite sponge comprising: i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

Composites, are provided, the composites comprising: mixed conducting particles; and an ion conducting scaffolding matrix. In some embodiments, the mixed conducting particles are made from poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate). In some embodiments, the ion conducting scaffolding matrix includes a chitosan (CS)-based polymer. In some embodiments, devices are provided, the devices comprising: a composite comprising mixed conducting particles and an ion conducting scaffolding matrix; and three electrodes, wherein: each of the three electrodes is in contact with the composite; a first pair of the three electrodes are on opposite sides of the composite and are a distance h apart; a second pair of the three electrodes are on a same side of the composite and are a distance d1 apart; a particle size of the mixed conducting particles is between h and d1; a mean-free-path of the mixed conducting particles is less than d1; and the composite behaves like an anisotropic conductor.

An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.

An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.

There is provided a hemostatic bioadhesive including from 0.5 to 5 w/v % of chitosan or alginate measured as a weight percent of chitosan or alginate with respect to a total dry volume of the hemostatic bioadhesive, the chitosan or alginate being crosslinked and forming a first polymer network; from 0.5 to 13 w/v % of polyacrylamide or polyethylene glycol measured as a weight percent of polyacrylamide or polyethylene glycol with respect to the total dry volume of the hemostatic bioadhesive, the polyacrylamide or polyethylene glycol being crosslinked and forming a second polymer network, wherein the first polymer network and the second polymer network form a dissipative polymer matrix; and from 0 to 100 v/v % of an adhesive liquid infused in the dissipative polymer network. The hemostatic bioadhesives comprise interconnected pores in the dissipative polymer matrix having a size of 20 to 400 m.

There is provided a hemostatic bioadhesive including from 0.5 to 5 w/v % of chitosan or alginate measured as a weight percent of chitosan or alginate with respect to a total dry volume of the hemostatic bioadhesive, the chitosan or alginate being crosslinked and forming a first polymer network; from 0.5 to 13 w/v % of polyacrylamide or polyethylene glycol measured as a weight percent of polyacrylamide or polyethylene glycol with respect to the total dry volume of the hemostatic bioadhesive, the polyacrylamide or polyethylene glycol being crosslinked and forming a second polymer network, wherein the first polymer network and the second polymer network form a dissipative polymer matrix; and from 0 to 100 v/v % of an adhesive liquid infused in the dissipative polymer network. The hemostatic bioadhesives comprise interconnected pores in the dissipative polymer matrix having a size of 20 to 400 m.

A malleable sustained release formulation is created utilizing a local anesthetic wherein the composition is made sustained release by incorporating it into a bovine or porcine hemostatic agent. The composition is malleable enough to fit into a cavity such as a dental cavity and form the shape of the cavity. In addition to providing sustained release of the anesthetic, the composition also provides quicker reduction in bleeding.

A bioadhesive and a method of its preparation. The bioadhesive includes a cyanoacrylate polymer, a starch mixture including Moringa oleifera starch and acid hydrolyzed date seed starch. The bioadhesive further includes a plant latex, a natural gum, a plant-derived hydrogel, glycerin, a dye, an organic solvent, and bone powder.