Medical stent designs are disclosed. An example stent includes a tubular scaffold having a proximal end and a distal end. The tubular scaffold includes a first filament extending between the proximal end and the distal end, the first filament including a first biodegradable region positioned adjacent to a second biodegradable region. Further, the first biodegradable region includes a first biodegradable material, the first biodegradable material having a first rate of degradation. The second biodegradable region includes a second biodegradable material, the second biodegradable material having a second rate of degradation, wherein the first rate of degradation is different from the second rate of degradation.

Disclosed herein are devices having an inner core comprising a biomatrix; and an outer scaffold comprising a biocompatible polymer. Also disclosed herein are methods for supporting a blood vessel and/or for treating or preventing an aneurysm by disposing a device having an inner core comprising a biomatrix; and an outer scaffold comprising a biocompatible polymer on an outer surface of a blood vessel of a subject. The bioengineered scaffolds of the present disclosure can limit the progression of vessel dilation while maintaining the biochemical characteristics of the vessel wall. Furthermore, the disclosed devices provide a minimally invasive alternative to conventional graft replacement, making the device suitable for patients having comorbidities.

An embodiment includes individual SMP foams that radially expand and fill gaps around a heart valve that may be improperly seated, in an unusual cross section, or has poor apposition against a calcified lesion. Other embodiments are described herein.