A biocompatible metal implant is provided with a treated surface subject to abrasive mechanical treatment, acid treatment, and sodium treatment, where the biocampatible metal implant treated surface has a macroporosity in the form of cells having dimensions of the order of 50 μm to 250 μm, the cells having pores of from 1 μm to 50 μm, and pores with a size of less than a micrometer, homogeneously over the whole of the treated surface, the treated surface having a surface roughness Ra of greater than or equal to 1.90 μm.

The device is intended for the noninvasive induction of dynamic deformation of body tissue to differentiate tissue cells. It comprises the following components: (i) a suspension of particles suspended in solution; and (ii) an external actuator which is capable of magnetically, electrically, vibrationally, or thermally stimulating the suspended particles.

An absorbable iron-based implantable device, including an iron-based substrate and a hydrophobically-modified high polysaccharide attached to the iron-based substrate. The solubility of the modified high polysaccharide in an organic solvent is increased when hydrophobically modified, this allows great film formation on the iron-based substrate when a coating method such as spraying or dip coating is employed for the preparation of a coating, thus allowing an increased amount of the modified high polysaccharide to be attached to the iron-based substrate. When the absorbable iron-based implantable device is implanted into the body, the degradation of the modified high polysaccharide produces an increased amount of degradation product that reacts with a corrosion product of the iron-based substrate to produce a water-soluble polysaccharide-iron complex, thus reducing the production of an insoluble solid corrosion product.

A biodegradable iron-based alloy composition, a medical implant applying the iron-based alloy composition, and a manufacturing method of the medical implant are provided. The biodegradable iron-based alloy composition includes at least 98 wt % of iron and 2 wt % or less of an additional material. The additional material includes 0.1 wt %-0.8 wt % of Mn, 0.01 wt %-0.15 wt % of Mo, 0.1 wt %-0.3 wt % of Cr, 0.02 wt %-0.15 wt % of C, and 0.01 wt %-0.15 wt % of Si.

A prosthetic valve comprising a conical shaped sheet structure and a support structure, the sheet structure having a closed distal end and a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, whereby the ribbon members form a plurality of fluid flow modulating regions that close when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure, the support structure having at least one elongated cardiovascular structure engagement member that is associated with one of the ribbon members and adapted to engage a cardiovascular structure.

The invention provides medical devices comprising high-strength alloys which degrade over time in the body of a human or animal, at controlled degradation rates, without generating emboli and which have enhanced degradation due to the presence of a halogen component. In one embodiment the alloy is formed into a bone fixation device such as an anchor, screw, plate, support or rod. In another embodiment the alloy is formed into a tissue fastening device such as staple. In yet another embodiment, the alloy is formed into a dental implant or a stent.

Methods of producing bioresorbable porous biocomposites for orthopaedic applications are provided. In an exemplary embodiment of a resorbable orthopaedic implant of the present disclosure, the implant comprises a porous alloy of at least a first metal and a second metal sintered together, the alloy configured to resorb into a body at substantially an atomic level without flaking off, wherein a porosity of the implant is defined by a first plurality of interconnected holes having a first range of sizes.

Disclosed is a nano-layered dual hydroxide-biological factor combined system for promoting nerve regeneration to repair a spinal cord injury. The preparation method therefor comprises: 1) synthesizing a nano-layered dual hydroxide CL1; and 2) co-incubating 10 mg CL1 and 200-2000 ng of biological factors NT3, VEGF or bFGF in a low-speed shaker at 4° C. for 2 hours using an ion exchange method, centrifuging same and then obtaining the precipitate. Experiments on transection and resorption spinal cord injury models show that this combined system has a significant recovery effect on the behavior of model mice, can reconstruct the neural circuit of a damaged area over time and achieves an ideal repair effect with regard to a spinal cord injury.

The present disclosure is directed to systems, method of manufacture, and packaging configurations for an antimicrobial orthopedic implant having an antimicrobial coating on the outer surface of the implant including a vaporizable antimicrobial agent in a surface area concentration on the outer surface sufficient to prevent bacterial growth on the orthopedic implant, and can additionally provide a clinically effective zone of inhibition around the orthopedic implant. In certain embodiments, a container, a reservoir of the vaporizable antimicrobial agent, and the orthopedic implant are configured to remain thermally stable in a temperature range up to 200C.

An absorbable iron-based device includes an iron-based matrix and degradable polyester in contact with the surface of the iron-based matrix. The mass fraction of a low-molecular-weight part of the degradable polyester is less than or equal to 5%, and the molecular weight of the low-molecular-weight part is less than 10,000; or the mass fraction of a residual monomer in the degradable polyester is less than or equal to 2%.