The application discloses an implantable device, comprising a galvanic redox system formed on a body substrate of the implantable device. The implantable device has a non-zero surface potential when it is deployed. The galvanic redox system comprises a first metal site and a second metal site, the first metal site comprising a first metal having a first metal electrode potential (FMEP) and the second metal site comprising a second metal having a second metal electrode potential (SMEP), which FMEP being lower than SMEP and SMEP being substantially different such that the implantable device is galvanized when it is deployed. Methods of making and using the implantabe device are also disclosed.

An embodiment includes individual SMP foams that radially expand and fill gaps around a heart valve that may be improperly seated, in an unusual cross section, or has poor apposition against a calcified lesion. Other embodiments are described herein.

Iron-based biodegradable metals and the method of fabricating are disclosed. The iron-based biodegradable metals, which have an accelerated degradation rate and a yield strength similar to stainless steel, comprises a composite structure of multiple iron layers separated by thin alloying metallic layers. The composite structure are built layer by layer using additive manufacturing technologies. The iron-based biodegradable metals can be fabricated into a small diameter tube for laser cutting into implantable bare metal stents or drug eluting stents with biodegradable polymer coating. The iron-based biodegradable metals can be fabricated and/or machined into orthopedic implants.

The present invention is directed to a biodegradable alloy suitable for use in a medical implant, comprising at least 50% iron by weight, at least 25% manganese by weight, and at least 0.01% sulfur and/or selenium by weight, wherein the biodegradable alloy is nonmagnetic. The present invention also provides a method of producing a biodegradable alloy with a desirable degradation rate.

A balloon implantation kit includes an inflatable biodegradable balloon configured to be implanted in a human body and a hydrogel composition. In some cases, the hydrogel composition is provided in a container configured to be introduced into the biodegradable balloon. For some applications, the biodegradable balloon includes a joint spacer for treatment of a joint of a human subject, such as a subacromial spacer, a glenohumeral spacer, or a spacer for another joint, such as a knee, hip, ankle, or hand (e.g., CMC1) joint. In these applications, the biodegradable balloon is configured to be inserted into a space of a joint of the human body, and is shaped to provide mechanical support to the joint until the biodegradable balloon resorbs into the human body. For other applications, the biodegradable balloon includes a soft tissue spacer.

The invention relates to a method and a device for producing an implant, wherein a natural bone microstructure of a natural bone region is detected (S1), an implant region in the natural bone region is marked (S2), the detected bone microstructure in the marked implant region is analysed to determine reproduction parameters (S3), and on the basis of the determined reproduction parameters, an artificial microstructure for producing the implant is created (S4).

The invention relates to a method for surface treatment of a biocompatible metal material, such as an implant, which comprises the following consecutive steps: i) abrasive mechanical treatment of the surface of said material using abrasive calcium phosphate grains, such as a mixture of hydroxyapatite and tricalcium phosphate; ii) acid treatment by hot dipping of said material in a bath comprising sulphuric acid and hydrochloric acid, followed by at least one rinse with demineralised water; iii) sodic treatment by hot dipping of said material in a soda bath followed by at least one rinse with demineralised water and drying in hot air. The implant thus treated has a surface with increased roughness with a triple level of porosity (macro-, micro- and nano-porosity) as well as improved hydrophilic properties. The method can be used for implants made of titanium alloys, such as the TA6V ELI alloy.

Bioresorbable porous biocomposites for orthopaedic applications. In an exemplary embodiment of a resorbable orthopaedic implant of the present disclosure, the implant comprises a porous alloy of at least a first metal and a second metal sintered together, the alloy configured to resorb into a body at substantially an atomic level without flaking off, wherein a porosity of the implant is defined by a first plurality of interconnected holes having a first range of sizes.

A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.

An absorbable iron-based implantable device, including an iron-based substrate and an iron absorption promoter that is attached to the iron-based substrate. The iron absorption promoter is a polymer containing an antioxidant structural unit on the molecular chain thereof. The antioxidant is gradually released as the iron absorption promoter is gradually degraded or broken, and may promote the absorption of iron.