The present invention relates to a process of treating an implant, comprising a step of treating the surface of the implant with at least one phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof under sonication at a temperature of about 50? C. to about 90? C. This process is highly advantageous in that it allows the formation of a monolayer of the phosphonic acid compound on the implant surface, having a particularly dense surface coverage which, in turn, results in an improved implant biocompatibility and improved osseointegration. The invention further relates to a surface-treated implant obtainable by this process and, in particular, it provides an implant having a surface made of a metal, a metal alloy or a ceramic, wherein a phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof is bound to the surface of the implant and forms a monolayer having an implant surface coverage, in terms of the ratio of the phosphorus content to the metal content as determined by X-ray photoelectron spectroscopy (XPS), of at least 70% of a reference maximum surface coverage.

The invention shows possibilities which allow simplified production of implants or prostheses, specifically of dental implants or prostheses, by applying subtractive processes. For this purpose, the invention proposes the use of a precipitation-hardening or solid-solution-strengthening, biocompatible cobalt-based alloy for the production of blanks. Such blanks are provided in the soft state. Subsequently, each component (implant or prosthesis) is produced from the soft blank by means of material-removing machining. Subsequently, a heat-treatment of the implant or prosthesis then takes place to adjust the hardness thereof by means of precipitation hardening or solid-solution formation.

A medical device having improved surface hardness and wear resistance properties. The medical device has a body that includes a molybdenum and rhenium alloy. The outer surface of the body has a nitride surface layer that includes nitrogen, molybdenum and rhenium.

Disclosed is an implanted device, comprising a device base body and an active drug, wherein the device base body is pure zinc and/or a zinc alloy, the zinc content in the device base body is 0.1-100%, and the active drug comprises anti-allergic drugs. After the implantation of the implanted device into the human body, the surrounding tissues of the implant would not have a clear hypersensitive reaction due to the presence of the anti-allergic drugs, and the implanted device can be used to be implanted into the body for supporting organ chambers, to fill the hollow chambers of the organs and tissues or as orthopaedic implants etc.

A medical product (100), preferably for use in treating, in particular filling and/or closing a bone cavity, wherein the product (100) comprises a plurality of interconnected members (110), wherein each member (110) has a peripheral boundary (120) and the boundaries (120) of adjacent members (110) engage with one another. Also, a method for producing the medical product (100) and a medical kit that comprises the medical product (100) and a securing element for securing the product (100) in a bone cavity and to a method for filling a bone cavity.

An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

The present invention includes a fluid interface system for use in medical implants. The fluid interface system of the present invention can include one or more fluid interface channels disposed within an implant. The fluid interface systems can optionally include fluid redirection channels, fluid interface ports and a corresponding instrument to transfer fluid in or out of the fluid interface ports.

A multilevel porous metal material, where the levels are classified based on the pore size of the material. The number of classified levels are at least more than two. The pore size of the smallest level of porous metal material is less than 1 micrometer. The elasticity modulus of the smallest level of porous metal material is less than 80 GPa. The porosity is no less than 48%. The preparation method thereof is as follows. The raw material powder used to prepare porous metal material and the pore-forming agent used to prepare the smallest level of pores cavities are mixed to prepare the slurry. The slurry is uniformly filled into polymer material support to form a green body. The green body is dried and crushed to obtain mixed grains.

An implantable permanent filter assembly (1) for deployment in a bifurcated vessel includes a main vessel and at least two branches. This assembly includes a filtering sleeve (2) formed of an expendable braided framework (20) able to expand from a radially compressed state in a delivery configuration to a radially expanded state. The filtering sleeve extends along an axis and defines a cylindrical lumen devoid of impermeable layer, having a distal end configured to extend toward the branches of the bifurcated vessel and a proximal end configured to extend toward away from the branches of the bifurcated vessel. The braided framework has a plurality of mesh layers (22,23,24) of wires (25) made of biocompatible material, forming a lattice with a plurality of wires of each layers. The lattice, when observed normal with respect to a wall of the implantable endoluminal prosthesis, defines polygonal openings.