The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

Provided is an implant magnesium alloy having corrosion resistance, mechanical strength, ductility at the same time. In one aspect of the present invention, an implant magnesium alloy contains: x at % of Zn; a total of y at % of at least one element of Ca and Sr; and the balance of Mg and inevitable impurities. x and y satisfy formulae 1 and 2:

0.15≤x≤1.5  (Formula 1)

0.5≤y≤1.5.  (Formula 2)

The present invention relates to a gel composition containing at least one selected from the group consisting of an extracellular matrix component and a fragmented extracellular matrix component, and an ion of a metal element.

A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.

A bioabsorbable implant including an elongated metallic element having more than 50% by weight a metal and being substantially free of rare earth elements, the elongated metallic element defining at least a portion of the bioabsorbable implant and including a wire formed into a discrete bioabsorbable expandable metal ring; at least two biostable ring elements, each biostable ring element having a biostable and radio-opaque metallic alloy, the bioabsorbable expandable metal ring being disposed adjacent to at least one of the biostable ring elements; at least one flexible longitudinal connector including a bioabsorbable polymer, the connector being disposed between at least two adjacent rings; and a coating having at least one pharmaceutically active agent disposed over at least a portion of one ring.

A coating with strong adhesion for medical magnesium alloys, including a magnesium phosphate or calcium phosphate layer as an inner layer and a hydrophobic polymer layer as an outer layer. The inner layer is attached to the medical magnesium alloy; and the outer layer is attached to the inner layer. A preparation method of the coating is also provided, including: (S1) carrying out surface treatment on a medical magnesium alloy substrate; (S2) preparing a solution including magnesium salt/calcium salt and phosphoric acid/phosphate followed by pH adjustment and heating; (S3) soaking the medical magnesium alloy substrate in the solution followed by washing and drying to obtain a magnesium phosphate/calcium phosphate layer-coated medical magnesium alloy sample; and (S4) depositing a hydrophobic polymer layer on the medical magnesium alloy sample through chemical vapor deposition (CVD).

A magnesium alloy containing, in % by mass, 0.95 to 2.00% of Zn, 0.05% or more and less than 0.30% of Zr, 0.05 to 0.20% of Mn, and the balance consisting of Mg and unavoidable impurities, wherein the magnesium alloy has a particle size distribution with an average crystal particle size from 1.0 to 3.0 μm and a standard deviation of 0.7 or smaller.

A nerve scaffold, including a membrane material and a degradable metal wire. The degradable metal wire is enclosed in the membrane material. The membrane material is biodegradable material, and includes three-dimensional pore structure. The degradable metal wire is horizontally and vertically distributed in the nerve scaffold.

Systems and methods discussed herein provide for fabricating orthopedic implants one or more shape-memory alloys including TiNi and TiNb and shape-setting the alloys to the geometry appropriate for the orthopedic implant. The shape-setting may include tuning the transformation temperature of the one or more alloys, and a single implant may comprise one or more alloys that may differ in composition, shape-setting process, or both.

Methods for controlling properties of structural elements of implantable medical devices, where the structural elements contain shape memory alloys (SMAs) include promoting or inhibiting in vivo formation of R-phase crystal structure or converging or separating the R-phase from the austenite phase.