The invention relates to biodegradable, metal alloys, methods for their preparation and applications for their use. The alloys include magnesium and other components, such as, yttrium, calcium, zirconium, and zinc. These elements are alloyed together in specific combinations and amounts in order to achieve an alloy having desired properties and characteristics. In certain embodiments, strontium or cerium may be included as an additive. The resulting alloys are particularly suitable for forming various medical devices for implantation into the body of a patient.

Compositions and methods for etching a nanoscale geometry on a metal or metal alloy surface are disclosed. Such surfaces, when included on an implantable medical device, enhance healing after surgery. When included on a bone contacting medical implant, the nanoscale geometry may enhance osseointegration. When included on a tissue contacting device, the nanoscale geometry may enhance endothelial cell attachment, proliferation, and restoration of a healthy endothelial surface.

The present disclosure discloses a shoulder joint prosthesis containing zirconium-niobium alloy on oxidation layer and a preparation method thereof, the preparation method comprises: using zirconium-niobium alloy powder as a raw material, conducting a 3D printing for one-piece molding to obtain an intermediate products of the humeral handle with articular surface and the scapular glenoid plate, and performing Sinter-HIP, cryogenic cooling and surface oxidation to obtain humeral handle with articular surface and scapular glenoid plate. The prosthesis comprises a humeral handle, an articular surface, a humeral head and a scapular glenoid plate, a bone trabeculae is arranged on the outer surface of the upper part of the humeral handle, the upper surface of the scapular glenoid plate and the outer surface of the circular pipe with internal thread.

The present disclosure discloses the hip prosthesis containing zirconium-niobium alloy on oxidation layer and a preparation method thereof, the hip prosthesis comprises a femoral stem, a femoral head, liners and a shell; the shell and femoral stem are prepared by using zirconium-niobium alloy powder as a raw material, and performing Sinter-HIP, cryogenic cooling and surface oxidation; the prepared shell and femoral stem are provided with partitioned trabeculae and formed by 3D printing. The problem of traditional manufacturing methods cannot process complex structures and failure of connection between sleeve and femoral handle is solved by 3D printing technology. Meanwhile, the preparation method can improve the bonding strength between trabecular bone and solid, and improve the service life of prosthesis.

A medical device that is partially or fully formed of a metal alloy; the metal alloy includes one of a) metal alloy that includes at least 15 awt % rhenium, b) at least 60 wt. % tungsten, at least 15 awt % rhenium, and at least 1 wt % molybdenum, c) at least 50 wt. % rhenium, at least 20 wt. % chromium, and 0.1-80 wt. % of an additive, d) greater than 50 wt. % titanium, 15-45 wt. % niobium, 1-10 wt. % zirconium, and 1-15 wt. % tantalum, e) greater than 50 wt. % titanium, 15-45 wt. % niobium, and 1-10 wt. %, f) 30-60 wt. % cobalt, 10-30 wt. % chromium, 5-20 wt. % iron, 5-22 wt. % nickel, and 2-12 wt. % molybdenum, g) 40-60 wt. % zirconium, and 40-60 wt. % molybdenum, h) 90-99.5 wt. % niobium, and 0.5-10 wt. % zirconium, or i) 55-75 wt. % niobium, 18-40 wt. % tantalum, 1-7 wt. % tungsten, and 0.5-4 wt. % zirconium.

The present disclosure relates in part to coating compositions comprising a bactericidal layer further comprising a bactericidal element and a columnar microstructure, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution (i.e. blood or other bodily fluid). The present disclosure further relates to coating compositions stably adhered to an electrode, which exerts bactericidal activity toward proximal and distal bacteria within an electrolyte solution upon application of an electric potential to the underlying electrode without a loss in efficiency of charge transfer.

Proposed is a nitinol nanofiber with an average surface roughness that is enhanced through mechanical and chemical treatments. The enhanced surface roughness improves biocompatibility and promotes tissue growing, thereby improving the bioavailability of the nitinol nanofiber. The nitinol nanofiber undergoes infrared irradiation whereby the nitinol fiber exhibits improved tensile strength, elastic modulus, and maximum restorative stress. Therefore, fatigue fraction does not easily occur in the nitinol fiber even when the nitinol nanofiber has a constant roughness. The present invention provides bio-use or medical nitinol nanofibers that are highly biocompatible.

The present invention relates to metal powders which are suitable to be employed in 3D printing processes as well as a process for the production of said powders.

A biocompatible Mg—P coating on the surface of a zinc-based biomedical material, and a preparation method and use thereof are disclosed. In the method, zinc and a zinc alloy are first subjected to surface pretreatment and then soaked in a phosphate solution at a constant temperature to form the Mg—P coating through chemical liquid deposition (CLD). The control on the composition, thickness and surface morphology of the coating is realized by using the CLD method. The biocompatible Mg—P coating has a thickness of 0.5 μm to 50 μm, is dense and uniform, and comprises a main component of zinc-magnesium-phosphate and a small amount of zinc phosphate.

A hybrid scaffold is disclosed which is made of materials that define peripheral layers designed to interface with the tissues in the implant site and one or more intermediate layers. The materials are combined to give the scaffold mechanical properties suitable for withstanding the stresses of the implant site. The materials are fibroin for the peripheral layers and polyurethane combined with fibroin for each intermediate layer.