The present invention relates to the field of medical titanium alloy materials, and in particular, to a narrow-diameter high-strength implant-specific medical titanium alloy achieving immediate implant placement and a preparation method for the implant-specific medical titanium alloy. The medical titanium alloy is prepared from the following chemical components (by weight percentage), 14%-17% of Zr, 3.0%-10% of Cu, and the balance of Ti. The preparation method for the medical titanium alloy comprises: after cogging and forging and before rolling, performing heat preservation for 0.5-6 h at the temperature of 900-1200° C., and water cooling to the room temperature; and rolling at the temperature of 720-850° C., a strain rate being larger than 0.1 s-1, and a barstock obtained after rolling being used for subsequent implant processing. According to the narrow-diameter high-strength implant-specific medical titanium alloy achieving immediate implant placement provided in the present invention, immediate implant placement can be achieved without any surface treatment, and a firm combination of the implant and a bone tissue is achieved. According to the preparation method for the medical titanium alloy provided in the present invention, the implant having a narrow diameter (3.0-3.5 mm) can be prepared and is high in strength, and the purpose of firm implanting on a narrow teethridge missing a tooth is achieved.

The present invention relates to the field of medical titanium alloy materials, and in particular, to a narrow-diameter high-strength implant-specific medical titanium alloy achieving immediate implant placement and a preparation method for the implant-specific medical titanium alloy. The medical titanium alloy is prepared from the following chemical components (by weight percentage), 14%-17% of Zr, 3.0%-10% of Cu, and the balance of Ti. The preparation method for the medical titanium alloy comprises: after cogging and forging and before rolling, performing heat preservation for 0.5-6 h at the temperature of 900-1200° C., and water cooling to the room temperature; and rolling at the temperature of 720-850° C., a strain rate being larger than 0.1 s-1, and a barstock obtained after rolling being used for subsequent implant processing. According to the narrow-diameter high-strength implant-specific medical titanium alloy achieving immediate implant placement provided in the present invention, immediate implant placement can be achieved without any surface treatment, and a firm combination of the implant and a bone tissue is achieved. According to the preparation method for the medical titanium alloy provided in the present invention, the implant having a narrow diameter (3.0-3.5 mm) can be prepared and is high in strength, and the purpose of firm implanting on a narrow teethridge missing a tooth is achieved.

Described herein is a bifunctional peptide, compositions comprising the same, and methods useful for treatment of peri-implant disease.

A small diameter vascular prosthesis includes an outer textile graft, an intermediate self-supporting coil or stent and an inner microporous layer. The outer textile graft allows for tissue ingrowth. The inner microporous layer provides blood impermeability without preclotting the prosthesis. The coil or stent provides kink resistance and resistance again collapsing of the outer textile graft and the inner microporous layer.

A small diameter vascular prosthesis includes an outer textile graft, an intermediate self-supporting coil or stent and an inner microporous layer. The outer textile graft allows for tissue ingrowth. The inner microporous layer provides blood impermeability without preclotting the prosthesis. The coil or stent provides kink resistance and resistance again collapsing of the outer textile graft and the inner microporous layer.

Provided herein are a scaffold having a surface hyperboloid structure and its fabrication method and application. The scaffold has internally disposed with pores where each of the pores connects with each other and any point on a surface of each of the pores has the hyperboloid structure. Since the surface of the scaffold is smooth and stress concentration is thereby avoided, the scaffold can withstand a greater external force in the case of the same porosity. Moreover, since the pores inside the scaffold connect with each other, the scaffold has a better permeability to fluid and is more conducive to tissue ingrowth. In addition, the scaffold has a large internal surface area, rendering it feasible to subsequent surface treatment, such as film coating, to be carried out on the internal surface of the scaffold.

Provided herein are a scaffold having a surface hyperboloid structure and its fabrication method and application. The scaffold has internally disposed with pores where each of the pores connects with each other and any point on a surface of each of the pores has the hyperboloid structure. Since the surface of the scaffold is smooth and stress concentration is thereby avoided, the scaffold can withstand a greater external force in the case of the same porosity. Moreover, since the pores inside the scaffold connect with each other, the scaffold has a better permeability to fluid and is more conducive to tissue ingrowth. In addition, the scaffold has a large internal surface area, rendering it feasible to subsequent surface treatment, such as film coating, to be carried out on the internal surface of the scaffold.

A medical device includes a substrate structure with a surface. The surface is laser treated to define at least one protrusion and/or at least one void extending relative to the surface. A coating having antibacterial, antimicrobial and/or drug eluding properties is applied to the substrate structure such that the coating engages within or along a surface portion of one or more of the protrusions and/or voids.

A method of forming an immunomodulatory implant operatively arranged to chemotactically facilitate bone morphogenesis, the method including forming a matrix of a first material, the matrix including an outer surface, and a plurality of pores, and applying an antigen to the matrix, wherein the antigen including at least one of a bacterial antigen or a viral antigen.

A method of forming an immunomodulatory implant operatively arranged to chemotactically facilitate bone morphogenesis, the method including forming a matrix of a first material, the matrix including an outer surface, and a plurality of pores, and applying an antigen to the matrix, wherein the antigen including at least one of a bacterial antigen or a viral antigen.