To provide Ti—Cu alloy formulations and additive manufacturing process configurations for fabrication of a bulk metallic glass (BMG) product that is biocompatible and antimicrobial, compositions of Ti-based metal alloy powder, comprising: Ti; Cu within a range of 5-30 atomic percent; transition metal within a range of 0-50 atomic percent, wherein such transition metal is one or a plurality of Zr, Nb, Ta, Pd, and Co, are disclosed. Moreover, additive manufacturing processes disclosed herein are capable of fabricating a bulk metallic glass of one or a combination of following phasic structures: fully amorphous microstructure; amorphous beta titanium phase; amorphous copper phase; and amorphous (Ti,M).sub.2Cu phase. The resulting biocompatible metal alloy product may be a medical device, particularly but not limited to a medical implant.

A surgical implant and a surgical kit. The surgical implant having a body for contacting and supporting adjacent vertebrae. The body has a) opposing superior and inferior surfaces with or without corrugations, b) recesses formed in the opposing superior and inferior surfaces within a peripheral boundary of the body, and a recess-fill material (which preferably promotes osseointegration) disposed in the recesses.

To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 10% to 90% is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film to suppress adhesion of bacteria.

Implantable medical devices coated with multiple atomic layers of amorphous titanium dioxide applied by atomic layer deposition have improved mammalian cell adhesion and inhibition of bacterial growth. Thickness of the coating can be used to tune resorption of bioresorbable vascular scaffolds for treatments of cardiovascular disease.

Disclosed herein are an ocular lens and a pharmaceutical composition. The ocular lens of the present disclosure is characterized in having a dihydrolipoic acid (DHLA) coated gold nanoclusters absorbed thereon. The pharmaceutical composition of the present disclosure comprises a DHLA coated gold nanocluster, and a pharmaceutically acceptable excipient. According to some embodiments of the present disclosure, the DHLA coated gold nanoclusters are capable of reducing intracellular ROS levels, promoting tissue repair, and inhibiting pathological angiogenesis. Accordingly, also disclosed herein are methods of treating ocular conditions by uses of the present contact lens or pharmaceutical composition.

Disclosed herein are methods for laser cladding a coating the surface of a biomedical implant. The biomedical implant may be an implant with a laser-cladded silicon nitride coating for promoting osteogenesis.

A bionic arm comprises a bionic palm and at least one finger. The at least one finger comprises a nanofiber actuator. A nanofiber actuator comprises a composite structure and a vanadium dioxide layer. The composite structure comprises a carbon nanotube wire and an aluminum oxide layer. The aluminum oxide layer is coated on a surface of the carbon nanotube wire, and the aluminum oxide layer and the carbon nanotube wire are located coaxially with each other. The vanadium dioxide layer is coated on a surface of the composite structure, and the vanadium dioxide layer and the composite structure are located non-coaxially with each other.

Various embodiment related to methods for coating a metal substrate with a silicon nitride ceramic coating are disclosed herein. The metal substrate may be a biomedical implant with a laser-cladded silicon nitride coating for promoting osteogenesis.

A medical device for repairing injuries to the spinal cord or peripheral nerve has a first flexible substrate supporting first nanoparticles selected from the group consisting of silicon, carbon, gold and titanium, at least partially embedded in a binding layer joined to the first flexible substrate. Each first nanoparticle develops along a preferential direction of development. The nanoparticles are oriented so that, statistically, the preferential direction of development is parallel to a first orientation of growth. Stem cells are at least partially embedded in the binding layer. The first nanoparticles are functionalized so that stem cell differentiation along the first nanoparticles is guided in the first orientation of growth. The first flexible substrate is suitable to assume a distended configuration and a wrapped configuration in which it is wrapped around the spinal cord or peripheral nerve whereby the first orientation of growth is statistically parallel to the neuronal direction of extension of neurons of the spinal cord or peripheral nerve.

The invention relates to a method of producing an implantable collagen-containing medical device comprising the step of coating said collagen-containing medical device with metal microparticles and/or metal nanoparticles, wherein said step of coating said collagen-containing medical device is by sonication such that the collagen-containing medical device has anti-bacterial and anti-inflammatory properties on implantation compared to the medical device not coated with metal microparticles and/or metal nanoparticles.