The invention discloses micron-nano pore gradient oxide ceramic films with biological activity, which are prepared by the following methods: The surface structures are biomedical engineering materials; Inorganic precursor coating solutions or the organic precursor coating solutions are prepared with or without micron and nanopore additives; The surface structures of the substrate are treated in the following steps: (1) The surfaces of the substrate are coated by the inorganic precursor coating solutions or the organic precursor coating solutions with or without micron and nanopore additives; (2) The substrate with coatings are dried, sintered, naturally cooled, and cleaned. (3) The biomedical engineering materials with the micron-nanopore gradient oxide ceramic films, especially biomimetic micro-nanoporous gradient alumina film, yttrium partially stabilized zirconia film, and alumina doped yttrium partially stabilized zirconia films in this invention greatly improve biocompatibility and biological activity.

A new titanium-based implant is disclosed, which is formed by a titanium coating manufactured with biomaterials with applications in osseous implantology. The nanotopographical characteristics of these implants inhibit bacterial adhesion and the formation of a bacterial biofilm on the surface, whilst simultaneously presenting suitable properties for the adhesion, stretching and proliferation of bone-forming cells. Moreover, the invention comprises a method for manufacturing the implant by means of oblique-incidence techniques and the use thereof in osseous implantology.

Various embodiments of the present invention include a cannula coated or compounded with a material to extend the wear time for a patient by reducing inflammation and therefore increasing the time that the cannula may remain inserted, thereby increasing the effectiveness of the drug delivered using the cannula. The material may include a hydrophilic material, an anti-microbial material, an anti-inflammatory material, anti-thrombogenic material, or a combination of any of these materials.

The current invention is directed to a medical implant made of bulk-solidifying amorphous alloys and methods of making such medical implants, wherein the medical implants are biologically, mechanically, and morphologically compatible with the surrounding implanted region of the body.

Body made of a ceramic material, the body having as an integral part thereof a surface region reaching from the surface of the body down to a predetermined depth. According to the invention, the surface region is enriched with a magnesium component thereby forming a hydrophilic surface area.

This orthopedic implant includes a polymer substrate with an outer surface intended to be secured to a bone tissue. The outer surface is covered with metal particles including titanium. The particles include large primary particles and small secondary particles. The primary particles and the secondary particles are evenly distributed over the outer surface.

A medical grade thermoplastic or polymer implant with an osteoconductive coating is provided, specifically for corrections of the distal and proximal interphalangeal toe joints of the foot. The implant can be either straight or angled, and can be either solid or cannulated for insertion. The implant is sized and shaped depending on the specific anatomy and desired correction. End portions of the implant may be coated with an osteoconductive coating that promotes bone growth, but may reduce radiolucency. Thus, a central portion of the implant may remain uncoated to increase radiolucency of the implant at the region where two bones come together.

A process for producing medical devices with functional surfaces, e.g., ceramic implants having bone-affine surfaces, and to medical devices produced in such a manner.

Borate-glass biomaterials comprising: aNa.sub.2O. bCaO. cP.sub.2O.sub.5. dB.sub.2O.sub.3 wherein a is from about 1-40 wt %, b is from about 10-40 wt %, c is from about 1-40 wt %, and d is from about 35-80 wt %; and wherein the biomaterial has a surface area per mass of more than about 5 m.sup.2/g. Methods of making and uses of these biomaterials.

The invention relates to a resurfacing prosthesis for the natural femoral head, having a spherical outer surface and an inner receiving space that has an inner surface facing the bone. In order to be able to make the resurfacing prosthesis without using metals, combine the advantages of bone-preserving surgery with those of a biocompatible material, keep wear of the sliding pair low, and anchor the prosthesis in an excellent and long-term stable manner in the bone, the resurfacing prosthesis is characterized by an integrated porous osseointegrative inner surface and by an entirely ceramic design of the resurfacing prosthesis.