The present application provides an implant comprising magnesium alloy comprising Ca in the range of 0.3-2 wt %, Zn in the range of 0.5-6 wt %, Fe in the range of 50-100 ppm, and Zr in the range of 100-900 ppm and total impurities including Fe and Zr in the range of 400-1000 ppm. The present application also provides a method for preparing an implant, the method comprising providing biodegradable magnesium alloy having an average grain size of 40 ?m or less and comprising Ca in the range of 0.3-2 wt %, Zn in the range of 0.5-6 wt %, Fe in the range of 50-100 ppm, and Zr in the range of 100-900 ppm and total impurities including Fe and Zr in the range of 400-1000 ppm, and forming the biodegradable magnesium alloy into the implant.

A method of treating a bacterial infection including bacteria that have become resistant to an antibiotic in a subject in need thereof is provided. The method includes administering to the subject a safe and therapeutically effective amount of the antibiotic and a reviving agent selected from the group consisting of glass-ceramic particles, silver ions, and combinations thereof. The reviving agent restores antibiotic activity to the antibiotic against the bacteria.

Systems, methods, and other embodiments associated with multi-phase ceramic composites are described herein. Specifically, a multi-phase ceramic composite having a microstructure having at least one solid-state lubricant phase and at least one wear resistant material phase.

Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.

The present invention relates to a resorbable implant material made of magnesium or magnesium alloy and to a process for the production thereof. A disadvantage of the known resorbable implants is that their resorption has hitherto only been trackable using x-ray or CT examinations. The invention provides a resorbable implant material comprising homogeneously distributed fluorescent nanodiamonds in a matrix of magnesium or a magnesium alloy. Fluorescent nanodiamonds are biologically nonhazardous and provide a stable emission in the near infrared range due to nitrogen-vacancy centers (NV centres). This allows detection of the implant material in the blood plasma of the patient. The resorbable implant material according to the invention is produced by a process wherein magnesium or a magnesium alloy is melted, nanodiamonds are added to the melt and the melt of magnesium or a magnesium alloy provided with nanodiamonds is subjected to an ultrasound treatment.

The present invention is directed to a shape memory alloy, particularly a Fe-based shape memory alloy, that is suitable for use in additive manufacturing methods, as well as methods of use and methods of altering the composition of the alloy during fabrication.

Disclosed are devices, systems and/or methods for use in the surgical treatment of vertebrae and/or other bones, particularly implants and/or related devices comprising silicon nitride in some of all of the implant or device body, including portions, layers and/or surface coatings thereof, for use in spinal surgeries and/or other orthopedic procedures.

An orthopaedic implant having a bone-engaging layer configured to contact bone and provide antimicrobial properties and methods for making the same.

Biodegradable, magnesium alloys and composites, articles produced therefrom, methods of making the same, and methods of using the same are described.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.