A medical implant comprising a plurality of biocomposite layers, each layer comprising a polymer and a plurality of uni-directionally aligned continuous reinforcement fibers. The medical implant is suitable for load-bearing orthopedic implant applications and comprises one or more biocomposite materials where sustained mechanical strength and stiffness are critical for proper implant function.

This invention relates to anti-microbial active particles, compositions and uses thereof for inhibiting bacterial growth on surfaces or devices. This invention further discloses methods of making such anti-microbial active particles.

A reinforced biocompatible scaffold facilitates integration of biological tissue. The reinforced scaffold comprises a porous biocompatible scaffold and an arrangement of at least one biocompatible filament embedded within and fixed to the biocompatible scaffold, and/or at least one biocompatible conduit embedded within and fixed to the biocompatible scaffold.

A reinforced biocompatible scaffold facilitates integration of biological tissue. The reinforced scaffold comprises a porous biocompatible scaffold and an arrangement of at least one biocompatible filament embedded within and fixed to the biocompatible scaffold, and/or at least one biocompatible conduit embedded within and fixed to the biocompatible scaffold.

The present invention relates to a carrier composition for particulate and granular bone substitute materials which is a hydrogel comprising a mixture of ethylene oxide (EO)-propylene oxide (PO) block copolymers and silica nanoparticles embedded therein. The present invention further relates to a bone substitute material containing osteoconductive and/or osteoinductive particles or granules in addition to the novel carrier composition. Processes for producing the novel carrier composition and the novel bone substitute material are likewise provided in the context of the invention.

A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

The invention relates to a method for producing an implant which contains a composite powder comprising microstructured particles, obtainable by a method in which large polymer particles are bonded to small spherical calcium carbonate particles. Said calcium carbonate particles can be obtained by a method with the following steps: a) providing a calcium hydroxide suspension, b) introducing carbon dioxide or a carbon dioxide-containing gas mixture into the suspension from step a), and c) separating the calcium carbonate particles formed, while adding 0.3 wt.-% to 0.7 wt.-% of at least one amino trialkylene phosphonic acid.

The invention relates to a method for producing an implant which contains a composite powder comprising microstructured particles, obtainable by a method in which large polymer particles are bonded to small spherical calcium carbonate particles. Said calcium carbonate particles can be obtained by a method with the following steps: a) providing a calcium hydroxide suspension, b) introducing carbon dioxide or a carbon dioxide-containing gas mixture into the suspension from step a), and c) separating the calcium carbonate particles formed, while adding 0.3 wt.-% to 0.7 wt.-% of at least one amino trialkylene phosphonic acid.

A threaded medical implant comprising a biocomposite, said biocomposite comprising a polymer and a plurality of reinforcement fibers, wherein a weight percentage of a mineral composition within the biocomposite medical implant is in the range of 30-60%, wherein an average diameter of said fibers is in a range of 1-100 microns, said medical implant being threaded with a plurality of threads; wherein said fibers comprise a plurality of helical fibers and a plurality of longitudinal fibers; wherein a weight to weight percent ratio of said helical to said longitudinal fibers is from 90:10 to 10:90.