The invention relates to a method for producing an implant by means of a composite powder having micro structured particles having inhibiting calcium carbonate, wherein the composite powder is obtained by a method in that large polymer particles are joined to small calcium carbonate particles, wherein the calcium carbonate particles are obtained by a method in that calcium carbonate particles are coated with a composition which, in each case based on the total weight thereof, comprises a mixture of at least 0.1 wt % of at least one calcium complexing agent and/or at least one conjugated base which is an alkaline metal or calcium salt of a weak acid, together with at least 0.1 wt % of at least one weak acid.

The invention relates to biodegradable, biocompatible materials to promote regeneration of articular surfaces in the temporomandibular joint and, more particularly, to biomaterials and methods for facilitating fibrochondrocyte and chondrocyte growth in in-vitro and in-vivo environments. The materials include magnesium in solid form and polymer. The materials are effective to grow and regenerate fibrochondrocyte and chondrocyte cells, and restore bone cells.

A medical device for implantation in tissue includes: a header including one or more bores, the header including an implant grade thermoplastic resin including a conductive additive and a metal coating; one or more leads disposed in the header and exiting the header through the one or more bores; and an enclosure coupled to the header at a surface of the enclosure, the enclosure including circuitry and a power source. A sterilized header for an implantable enclosure is also described.

The present invention relates to a (poly)hybrid implant made of one or more composite materials, having a polymer matrix and a ceramic-inorganic and/or inorganic component, wherein the polymer matrix has at least one component, selected from the group PDLLA; PLGA, PCL, HDPE, PE, UHMWPE, PEAK, PEEK, PP, PUR, and the ceramic-inorganic component has at least one calcium-phosphate-based component, preferably selected from the group HAP, α-TCP, β-TCP and CaCO.sub.3. In addition, metallic components can also be introduced, preferably, but not exclusively containing elements such as Mg, Fe, Zn or Sr.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

The present invention discloses elastic macro porous scaffold and a process for the preparation thereof. The present invention also provides a process for the preparation of macroporous, elastic nano particulate scaffolds comprising of coated or grafted cross linkable nanoparticles, and a crosslinker prepared by crosslinking during ice templating, wherein the modulus increases linearly with temperature.

Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (MEPs) or a component thereof on skeletal muscle cells or tissue, as well as the use of scaffolds so produced for repairing a tissue injury or defect.

A prosthetic implant with improved properties, suitable for implantation to the human body, comprising a composite comprising a base material and a plurality of additives, wherein the additives are selected from radiolucent additives and/or hyperechoic additives; or wherein the additives are selected to reduce the solvent concentration by between 5%-95%; or wherein the additives are selected to increase the elastic modulus by more than 20%; or wherein the additives are selected for combining these effects.

A prosthetic implant with improved properties, suitable for implantation to the human body, comprising a composite comprising a base material and a plurality of additives, wherein the additives are selected from radiolucent additives and/or hyperechoic additives; or wherein the additives are selected to reduce the solvent concentration by between 5%-95%; or wherein the additives are selected to increase the elastic modulus by more than 20%; or wherein the additives are selected for combining these effects.