The invention relates to an implant preform made of plastic, which comprises an assembly of at least one biocompatiblebeing intended for contact with a biological materialthermoplastic plastics unit (A) having an elasticity modulus E.sub.A and at least one thermoplastic plastics unit (B) having an elasticity modulus E.sub.B, where for the elasticity moduli of these plastics units E.sub.A<E.sub.B, and the plastics units in their assembly zone are seamlessly connected thermally to one another. The invention also relates to the production of the implant preform made of plastic and also to the use of the implant preform as an implant or for fabrication of an implant therefrom, more particularly to the use thereof as a dental implant or for fabrication of a dental implant. The invention can also be applied to other bone implants.

A bone void filler material is provided for sustained release of a therapeutic agent. The bone void filler material comprising a biodegradable matrix having ceramic cement beads comprising calcium sulfate, and ceramic particles disposed within the matrix. The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.

A bone void filler material is provided for sustained release of a therapeutic agent. The bone void filler material comprising a biodegradable matrix having ceramic cement beads comprising calcium sulfate, and ceramic particles disposed within the matrix. The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.

An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.

The present disclosure provides matrix compositions comprising bioactive glass and methods for treating a defect in tissue demonstrating volumetric tissue loss arising from injury or congenital defect.

The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.

The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.

Disclosed herein is a method for regenerating retinal tissue which includes preparing a luminescent scaffold, implanting the luminescent scaffold in a portion of retina, for example subretinal area, emitting a green light from the luminescent nanoparticles in a luminescence phenomenon, and absorbing the emitted light by retinal cells for regenerating retinal tissue by stimulating the retinal cells. Moreover, preparing a luminescent scaffold may comprise synthesizing a plurality of luminescent particles, dispersing the luminescent particles in a polymeric matrix to form a luminescent composite, and electrospinning the luminescent composite to form the luminescent scaffold.

Provided herein is a novel bioresorbable polymer composite for bone soft tissue fixation including i) Silk fibroin in an amount of 5 to 30%, ii) a bioresorbable polymer matrix in an amount of 40 to 90%, and iii) magnesium oxide or other ceramic fillers in an amount of 5 to 30%.

The invention relates to an implant material for filling bone defects, for bone regeneration, and for bone tissue engineering, to an implant comprising said material, and to methods for manufacturing such an implant. The hybrid implant material according to the invention comprises: a biodegradable polymer P soluble in at least one solvent S1 and insoluble in at least one solvent S, different from the solvent S1; and a bioactive glass made of SiO.sub.2 and CaO and optionally containing P.sub.2O.sub.5 and/or optionally doped with strontium, characterized in that said implant includes a layering of a porous part having more than 90% by number of pores whose largest dimension is greater than or equal to 100 m, and a dense part (2, 20, 200, 2000, 20000) having more than 80% by number of pores whose largest dimension is less than 50 m. The invention is useful in the field of bone regeneration, particularly in the field of bone tissue engineering.