An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects, a method of preparation thereof, and a method of inducing or promoting bone growth by treatment of a bone with an autologous bone graft substitute composition. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof; and a compression resistant matrix selected from the group consisting of a bone autograft, bone allograft, hydroxyapatite, tri-calcium phosphate, and combinations thereof. The autologous blood forms a coagulum gel comprising a fibrin-meshwork reinforced with the compression resistant matrix and containing the osteogenic bone morphogenetic protein which is released over a sustained period.

Provided is an alveolar bone augmentation scaffold system. The scaffold system includes the following structures: a porous augmentation scaffold fabricated by 3D printing using composite materials for filling alveolar bone defects; a mechanical separating plate, wrapped around the porous augmentation scaffold with a biomimetic structure for restoring alveolar bone defects; the augmentation scaffold is provided with a first region close to dental pulp, a second region away from the dental pulp, and a third region surrounding the second region, wherein pore diameters of three-dimensional porous structure of the above three regions are R1, R2, and R3 respectively, and they satisfy R1≥R2>R3.

Provided is an alveolar bone augmentation scaffold system. The scaffold system includes the following structures: a porous augmentation scaffold fabricated by 3D printing using composite materials for filling alveolar bone defects; a mechanical separating plate, wrapped around the porous augmentation scaffold with a biomimetic structure for restoring alveolar bone defects; the augmentation scaffold is provided with a first region close to dental pulp, a second region away from the dental pulp, and a third region surrounding the second region, wherein pore diameters of three-dimensional porous structure of the above three regions are R1, R2, and R3 respectively, and they satisfy R1≥R2>R3.

The invention is for a synthetic composite for a bone graft comprising of: bio inert polymers comprising poly lactic acid, poly D, L-Lactic acid; bio active polymer consisting of polypropylene fumarate or diester of fumaric acid and propylene diol (1,2-Diol); and a bioactive inorganic component consisting of a metal fluorophosphates glass powder wherein the amount of the bioactive components is upto 30% (w/w) of the composite. The bioactive inorganic metal fluorophosphates glass powder of the composite is one of zinc fluorophosphate, magnesium fluorophosphate or silver fluorophosphate. The invention pertains to the method of making the scaffold, and also the 3D printed scaffold.

The invention is for a synthetic composite for a bone graft comprising of: bio inert polymers comprising poly lactic acid, poly D, L-Lactic acid; bio active polymer consisting of polypropylene fumarate or diester of fumaric acid and propylene diol (1,2-Diol); and a bioactive inorganic component consisting of a metal fluorophosphates glass powder wherein the amount of the bioactive components is upto 30% (w/w) of the composite. The bioactive inorganic metal fluorophosphates glass powder of the composite is one of zinc fluorophosphate, magnesium fluorophosphate or silver fluorophosphate. The invention pertains to the method of making the scaffold, and also the 3D printed scaffold.

The invention is for a synthetic composite for a bone graft comprising of: bio inert polymers comprising poly lactic acid, poly D, L-Lactic acid; bio active polymer consisting of polypropylene fumarate or diester of fumaric acid and propylene diol (1,2-Diol); and a bioactive inorganic component consisting of a metal fluorophosphates glass powder wherein the amount of the bioactive components is upto 30% (w/w) of the composite. The bioactive inorganic metal fluorophosphates glass powder of the composite is one of zinc fluorophosphate, magnesium fluorophosphate or silver fluorophosphate. The invention pertains to the method of making the scaffold, and also the 3D printed scaffold.

The present disclosure provides bio-material composition, comprising a dry potassium phosphate based mixture comprising: MgO, monobasic potassium phosphate, monobasic sodium phosphate, proteoglycans, calcium sodium phosphosilicate, and a plurality of spherically-shaped polymers, wherein a weight percent ratio of monobasic potassium phosphate to MgO is between about 3:1 and 1:1, wherein the dry potassium phosphate based mixture is configured to be mixed with the aqueous solution to thereby form a reabsorbable bio-material slurry, wherein the spherically-shaped polymers are between about 1-5 weight percent of the dry composition, and wherein the spherically-shaped polymers are absorbed faster than the remaining components of the reabsorbable bio-material slurry to thereby form pockets within the bio-material composition that enhance reabsorption of the bio-material composition.

A filament or printing material placed in a syringe for 3D printing comprising polymers, proteins, and/or functional particles and materials is provided. Methods of treating a bone defect in a subject in need thereof comprising using a handheld 3D printer to apply a filament or the printing material placed in a syringe to the bone defect of the subject are also provided. Methods of fixing or gluing natural or synthetic bone grafts using a handheld 3D printer to apply a filament or the printing material placed in a syringe over and around the defect or at the interface of a flap and the bone. Methods of printing a graft cage for retaining bone grafts and/or bone graft substitute in its desired location during healing for treatment of critical-sized segmental defects in long bones are provided.

A filament or printing material placed in a syringe for 3D printing comprising polymers, proteins, and/or functional particles and materials is provided. Methods of treating a bone defect in a subject in need thereof comprising using a handheld 3D printer to apply a filament or the printing material placed in a syringe to the bone defect of the subject are also provided. Methods of fixing or gluing natural or synthetic bone grafts using a handheld 3D printer to apply a filament or the printing material placed in a syringe over and around the defect or at the interface of a flap and the bone. Methods of printing a graft cage for retaining bone grafts and/or bone graft substitute in its desired location during healing for treatment of critical-sized segmental defects in long bones are provided.

A filament or printing material placed in a syringe for 3D printing comprising polymers, proteins, and/or functional particles and materials is provided. Methods of treating a bone defect in a subject in need thereof comprising using a handheld 3D printer to apply a filament or the printing material placed in a syringe to the bone defect of the subject are also provided. Methods of fixing or gluing natural or synthetic bone grafts using a handheld 3D printer to apply a filament or the printing material placed in a syringe over and around the defect or at the interface of a flap and the bone. Methods of printing a graft cage for retaining bone grafts and/or bone graft substitute in its desired location during healing for treatment of critical-sized segmental defects in long bones are provided.