Disclosed herein is a composite scaffold material that includes a crosslinked polymer matrix formed from a non-mammalian collagen and a crosslinking agent and/or a crosslinked polymer matrix formed from a non-mammalian collagen that has undergone self-crosslinking, and a plurality of calcium phosphate particles distributed within the crosslinked polymer matrix, where the composite scaffold material is porous. Also disclosed herein are methods of manufacturing the composite scaffold material and uses thereof. Further disclosed herein is a method of obtaining collagen from a non-mammalian source.

Disclosed herein is a composite scaffold material that includes a crosslinked polymer matrix formed from a non-mammalian collagen and a crosslinking agent and/or a crosslinked polymer matrix formed from a non-mammalian collagen that has undergone self-crosslinking, and a plurality of calcium phosphate particles distributed within the crosslinked polymer matrix, where the composite scaffold material is porous. Also disclosed herein are methods of manufacturing the composite scaffold material and uses thereof. Further disclosed herein is a method of obtaining collagen from a non-mammalian source.

Disclosed herein is a composite scaffold material that includes a crosslinked polymer matrix formed from a non-mammalian collagen and a crosslinking agent and/or a crosslinked polymer matrix formed from a non-mammalian collagen that has undergone self-crosslinking, and a plurality of calcium phosphate particles distributed within the crosslinked polymer matrix, where the composite scaffold material is porous. Also disclosed herein are methods of manufacturing the composite scaffold material and uses thereof. Further disclosed herein is a method of obtaining collagen from a non-mammalian source.

Ink formulations comprising bioactive particles, methods of printing the inks into three-dimensional (3D) structures, and methods of making the inks are provided. Also provided are objects, such as tissue growth scaffolds and artificial bone, made from the inks, methods of forming the objects using 3D printing techniques, and method for growing tissue on the tissue growth scaffolds. The inks comprise a plurality of bioactive ceramic particles, a biocompatible polymer binder, optionally at least one bioactive factor, and a solvent.

Ink formulations comprising bioactive particles, methods of printing the inks into three-dimensional (3D) structures, and methods of making the inks are provided. Also provided are objects, such as tissue growth scaffolds and artificial bone, made from the inks, methods of forming the objects using 3D printing techniques, and method for growing tissue on the tissue growth scaffolds. The inks comprise a plurality of bioactive ceramic particles, a biocompatible polymer binder, optionally at least one bioactive factor, and a solvent.

Ink formulations comprising bioactive particles, methods of printing the inks into three-dimensional (3D) structures, and methods of making the inks are provided. Also provided are objects, such as tissue growth scaffolds and artificial bone, made from the inks, methods of forming the objects using 3D printing techniques, and method for growing tissue on the tissue growth scaffolds. The inks comprise a plurality of bioactive ceramic particles, a biocompatible polymer binder, optionally at least one bioactive factor, and a solvent.

A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

Disclosed are composite filaments for 3D printing. The filaments typically have high strength, an appropriate resorption rate, and high biocompatibility. The filaments generally contain a matrix formed of a blend containing a bioresorbable polymer and an inorganic component. The filaments can be used to produce customized scaffolds for repairing bone defects following implantation in the site of the defect. The shape and size of the scaffold can be configured to fit in and conform to the bone defect. The scaffolds are especially useful in repairing critical sized bone defect, such as a critical sized bone defect in a weight-bearing long bone.

Disclosed are composite filaments for 3D printing. The filaments typically have high strength, an appropriate resorption rate, and high biocompatibility. The filaments generally contain a matrix formed of a blend containing a bioresorbable polymer and an inorganic component. The filaments can be used to produce customized scaffolds for repairing bone defects following implantation in the site of the defect. The shape and size of the scaffold can be configured to fit in and conform to the bone defect. The scaffolds are especially useful in repairing critical sized bone defect, such as a critical sized bone defect in a weight-bearing long bone.