A bone-regeneration material comprising a biodegradable fiber produced using an electrospinning process, wherein the biodegradable fiber comprises 30 to 50 wt % of PLLGA resin and 70 to 50 wt % of ?-TCP fine particles substantially uniformly dispersed in the PLLGA resin without forming aggregates, wherein the ?-TCP fine particles are not chemically bonded to the PLLGA resin, and surroundings of the ?-TCP fine particles are covered by the PLLGA resin so that the ?-TCP fine particles are not separated from the biodegradable fiber during a formation of the fiber, and wherein the bone-regeneration material is sterilized by using radiation sterilization with gamma ray.

A bone-regeneration material comprising a biodegradable fiber produced using an electrospinning process, wherein the biodegradable fiber comprises 30 to 50 wt % of PLLGA resin and 70 to 50 wt % of ?-TCP fine particles substantially uniformly dispersed in the PLLGA resin without forming aggregates, wherein the ?-TCP fine particles are not chemically bonded to the PLLGA resin, and surroundings of the ?-TCP fine particles are covered by the PLLGA resin so that the ?-TCP fine particles are not separated from the biodegradable fiber during a formation of the fiber, and wherein the bone-regeneration material is sterilized by using radiation sterilization with gamma ray.

A flat self-curling rollable composite sheet membrane, and methods for preparing such membranes. The sheet membrane includes a flat layer of collagen and a bioactive agent, such as a calcium phosphate-based mineral. The flat layer self-curls into a predetermined shape upon absorption of an aqueous fluid. The methods for preparing the membranes include the steps of adding mineral to a collagen dispersion, forming a composite collagen matrix having mineral particles dispersed therein, compressing the composite matrix between two plates to form a flat sheet, and drying the flat sheet to yield a rollable composite sheet membrane.

A flat self-curling rollable composite sheet membrane, and methods for preparing such membranes. The sheet membrane includes a flat layer of collagen and a bioactive agent, such as a calcium phosphate-based mineral. The flat layer self-curls into a predetermined shape upon absorption of an aqueous fluid. The methods for preparing the membranes include the steps of adding mineral to a collagen dispersion, forming a composite collagen matrix having mineral particles dispersed therein, compressing the composite matrix between two plates to form a flat sheet, and drying the flat sheet to yield a rollable composite sheet membrane.

A composite implant for providing simultaneous magnetic resonance imaging (MRI) and computed tomographic (CT) imaging contrast is disclosed. The composite implant is formed of a calcium compound in the form of nano or microparticles doped with a first dopant configured to provide MRI contrast and a second dopant configured to provide CT contrast. The calcium compound is loaded onto a polymer gel matrix and lyophilized to form a mass with 3-dimensionally interconnected porosity, configured to provide tissue integration and proliferation sites. Methods of forming the composite implant are also disclosed. The implant could be a scaffold or bead structured to enable treatment of human or animal patient for bone/cartilage injury or defect by implantation, with MRI and CT monitoring.

A composite material includes: an apatite crystal in the form of a tube; and a functional component accommodated in the apatite crystal tube and constituted by a material having physical properties different from those of the apatite crystal. The apatite crystal may be a monocrystal given by the general formula M.sup.2.sub.5(PO.sub.4).sub.3X, where M.sup.2 denotes at least one element selected from the group consisting of divalent alkali earth metals and Eu, and X denotes at least one element or molecule selected from the group consisting of halogens and OH.

A composite material includes: an apatite crystal in the form of a tube; and a functional component accommodated in the apatite crystal tube and constituted by a material having physical properties different from those of the apatite crystal. The apatite crystal may be a monocrystal given by the general formula M.sup.2.sub.5(PO.sub.4).sub.3X, where M.sup.2 denotes at least one element selected from the group consisting of divalent alkali earth metals and Eu, and X denotes at least one element or molecule selected from the group consisting of halogens and OH.

The presently disclosed subject matter provides a coating composition which allows for the co-delivery of two or more bioactive agents with independent control of loading level and release profile for each bioactive agent, an implantable medical device coated with the coating composition, and methods for preparing the coating composition.

Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.

Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.