Invasive medical devices including a substantially non-eluting antimicrobial treatment. One or more external and/or internal surfaces of the medical device include a substantially non-eluting copper-coated surface that assists in preventing microbial colonization of the coated surface. This in turn reduces the incidence of infection to the patient originating from the medical device. In one embodiment, a catheter assembly is disclosed and comprises an elongate catheter tube that defines at least one lumen, at least one extension leg including a luer connector, and a bifurcation hub including at least one fluid passageway that provides fluid communication between the extension leg and the lumen. A substantially non-eluting copper coating is disposed on a surface of at least one of the lumen, the extension leg, the luer connector, and the fluid passageway. The coating is applied via an electroless deposition process. A water-shed coating is disposed on the copper coating.

There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm.sup.2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.

A medical device, the medical device including a substrate defining a surface; a plasma polymer layer bound to and coating the surface; and a bactericide layer bound to the plasma polymer layer, the plasma polymer layer being between the substrate and the bactericide layer. Also, a method for coating a surface of a substrate of a medical device with a bactericide layer, the method including: exposing the surface to a plasma to form a plasma polymer layer bound to the surface; and binding a bactericide layer to the plasma polymer layer.

A dose applicator for preparing a mixture at a point of use includes a housing defining an interior and an opening. First and second ampoules are contained in the interior, wherein the first ampoule contains a first component and the second ampoule contains a second component comprising one or more antifungal agent. An applicator tip is secured in the opening so that when the first and second ampoules are broken, the first and second components mix to form the mixture and the mixture can egress from the application tip.

Devices and methods are disclosed that detect and/or prevent intraoperative full thickness penetration of anatomic walls and provide delineation of anatomic structures during surgery.

The present invention provides composition comprising a metal oxide semiconductor nanomaterial coated or dispersed with a hemostatic polymer.

Provided is a nasal implant assembly comprising a hollow implant having a distal end and a proximal end, the distal end configured to have a segment deposited with magnetic particles; and a medical syringe configured to be attachable to the proximal end of the hollow implant and also configured to be capable of retaining and transporting a magnetically active fluid composition through the implant to a nasal cavity of a subject. Also provided is a method of treating chronic rhinosinusitis in a subject, the method comprising the steps of positioning a nasal implant having magnetic particles into a nasal cavity; loading a medical syringe with a magnetically active fluid composition; and transporting the loaded magnetically active fluid composition to the nasal cavity to treat chronic rhinosinusitis.

Stabilized multi-component antimicrobial compositions for treating tissue diseases, infections or conditions include a first and second set of differently sized and/or differently shaped metal nanoparticles, and a stabilizing agent. Compositions and treatment methods may be used for treating tissue diseases, infections or conditions caused by microbial infections, such as bacteria, viral, and/or fungal infections, or for preventing the infection of a wound, such as a cut, abrasion, ulcer, lesion, sore, and the like. The compositions and treatment methods disclosed herein may also be used as a prophylactic, and in some embodiments may be applied to otherwise healthy tissue in order to prevent or reduce the occurrence of a tissue disease, infection or condition.

An insert molded product in which a metal base member and a resin are bonded together includes a ground layer; a noble metal layer formed of a noble metal; a compound layer formed of a compound containing silicon (Si) and oxygen (O); and a mixture layer where the compound and the resin are mixed together, wherein the ground layer, the noble metal layer, the compound layer, and the mixture layer are formed in this order on the metal base member, and wherein nickel (Ni) is included in both the compound layer and the mixture layer.

An insertion and retraction device is described for delivery and removal of a microparticle from target tissue. The device comprises a magnetic or magnetizable needle or cannula having a distal end, a proximal end and a lumen adapted to convey microparticles; a tubular catheter receiving the needle or cannula; a pressure device adapted for delivery of microparticles through the needle or cannula lumen by pressure; a magnetic field modulator adapted to move the needle or cannula by modulation of a magnetic field; and a magnetic sensor positioned toward the distal end of the tubular catheter responsive to a magnetic moment of the microparticle.