The present application provides compositions configured to be provided in a flowable, liquid form but that are configured to transition to a solid or semi-solid gel based upon a change in pH. The change in pH can arise from one or more materials utilized in the composition itself or based upon encountering an environment with a significantly different pH. The compositions are particularly suited for use as a teat sealant in non-human mammals, particularly cattle.

The present invention relates to a silk fibroin/hydroxyapatite composite material, and a preparation method therefor and an application thereof. A uniform mixture of hydroxyapatite nanoparticles, silk fibroin, and hexafluoroisopropanol is maintained at a temperature range from 50? C. to 60? C. for at least 1 hour to obtain a silk fibroin/hydroxyapatite solution; the silk fibroin/hydroxyapatite solution is poured into a long cylindrical mold, two ends of the long cylindrical mold being respectively an end A and an end B; at room temperature, the end A is opened and the end B is closed, and the mold is vertically immersed in methanol with the opening facing up and let stand for at least 2 days; the mold is turned upside down, the end A is closed and the end B is opened, and the mold is vertically immersed in the methanol with the opening facing up and let stand for at least 2 days; the mold is removed, and ventilation and drying are performed to obtain a silk fibroin/hydroxyapatite composite material. The silk fibroin/hydroxyapatite composite material prepared in the present invention has uniform strength, good mechanical properties, and significant osteoinductivity.

The present invention relates to a silk fibroin/hydroxyapatite composite material, and a preparation method therefor and an application thereof. A uniform mixture of hydroxyapatite nanoparticles, silk fibroin, and hexafluoroisopropanol is maintained at a temperature range from 50? C. to 60? C. for at least 1 hour to obtain a silk fibroin/hydroxyapatite solution; the silk fibroin/hydroxyapatite solution is poured into a long cylindrical mold, two ends of the long cylindrical mold being respectively an end A and an end B; at room temperature, the end A is opened and the end B is closed, and the mold is vertically immersed in methanol with the opening facing up and let stand for at least 2 days; the mold is turned upside down, the end A is closed and the end B is opened, and the mold is vertically immersed in the methanol with the opening facing up and let stand for at least 2 days; the mold is removed, and ventilation and drying are performed to obtain a silk fibroin/hydroxyapatite composite material. The silk fibroin/hydroxyapatite composite material prepared in the present invention has uniform strength, good mechanical properties, and significant osteoinductivity.

The present disclosure provides a bioabsorbable composite screw and methods of use. The bioabsorbable composite screw includes an elongated body having a proximal end and a distal end. The elongated body includes an outer surface provided with a plurality of threads defined by a plurality of crests and a plurality of roots. The bioabsorbable composite screw also includes a drive socket positioned at the proximal end of the elongated body. The bioabsorbable composite screw including both the elongated body and the drive socket is made from a polymer including poly-lactic acid and either magnesium phosphate or potassium phosphate.

The present disclosure provides a bioabsorbable composite screw and methods of use. The bioabsorbable composite screw includes an elongated body having a proximal end and a distal end. The elongated body includes an outer surface provided with a plurality of threads defined by a plurality of crests and a plurality of roots. The bioabsorbable composite screw also includes a drive socket positioned at the proximal end of the elongated body. The bioabsorbable composite screw including both the elongated body and the drive socket is made from a polymer including poly-lactic acid and either magnesium phosphate or potassium phosphate.

Reinforced biocomposite materials having a unique treated surface, in which the surface may comprise a plurality of layers. According to at least some embodiments, medical implants are provided that incorporate novel structures, alignments, orientations and forms comprised of such reinforced bioabsorbable materials, as well as methods of treatment thereof.

Reinforced biocomposite materials having a unique treated surface, in which the surface may comprise a plurality of layers. According to at least some embodiments, medical implants are provided that incorporate novel structures, alignments, orientations and forms comprised of such reinforced bioabsorbable materials, as well as methods of treatment thereof.

A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the polymer coat the filamentary structure and the polymer is adhered to the synthetic bone graft particles to retain the graft particles.

Provided is a nanofiber composite membrane for guided bone regeneration, which includes: spinning a spinning solution by an electrospinning method to produce nanofibers; accumulating the nanofibers, to prepare a certain thickness of a nanofiber web; and drying and thermally calendering the nanofiber web to sterilize the nanofiber web, wherein the spinning solution contains a biocompatible plasticizer to maintain physical properties, flexibility and elasticity of the membrane, by suppressing an increase in brittleness in a sterilization treatment.

Provided is a nanofiber composite membrane for guided bone regeneration, which includes: spinning a spinning solution by an electrospinning method to produce nanofibers; accumulating the nanofibers, to prepare a certain thickness of a nanofiber web; and drying and thermally calendering the nanofiber web to sterilize the nanofiber web, wherein the spinning solution contains a biocompatible plasticizer to maintain physical properties, flexibility and elasticity of the membrane, by suppressing an increase in brittleness in a sterilization treatment.