Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %.

The present invention relates to a coating for a device, wherein the coating comprises a polymeric film, wherein the polymeric film comprises a polymerisation product formed from a polymerisation solution comprising dopamine, or a salt thereof, and at least one amino acid, or a salt thereof; and a metallic layer formed on the polymeric film.

A method for introducing a soft metal into a hard coating during a physical vapor deposition process. The method including steps of providing a substrate; depositing a bonding layer on the substrate; and depositing the hard coating on the bonding layer using vapor deposition wherein the soft metal forms islands in the hard coating.

An antimicrobial coating is formed from a biocompatible flexible polymer having incorporated therein an active material having a reducible form of silver, where at least a portion of the active material is exposed at the surface of the polymer. The coating can be applied to the surface of a catheter to inhibit bacterial growth and biofilm formation.

The present invention provides a medical dressing article and a method of manufacturing the same, which comprises: (a) a first layer comprised of polycaprocaptone fibers having a PCL fiber diameter of 0.5 μm and 2.9 μm; (b) a second layer, deposited directly on the first layer, including a mixture of polycaprolactone and poloxamer fibers (PCL and POX fibers) wherein a PCL and POX fiber diameter is between 0.1 μm and 4 μm; and (c) a third layer, deposited directly on the second layer, further comprising a mixture of gelatin and silver nitrate (AgNO.sub.3).

The present invention is directed to suturing systems having a needle, an elongated flexible suture having a connecting end attached to a said needle and an opposing free end and at least one elongated external beneficial filament that is attached to said needle or attached to said suture at the connecting end. The beneficial filament has a smaller cross-sectional area and lower mechanical strength than the suture and contains a medicant.

A medical device includes a substrate structure with a surface. The surface is laser treated to define at least one protrusion and/or at least one void extending relative to the surface. A coating having antibacterial, antimicrobial and/or drug eluding properties is applied to the substrate structure such that the coating engages within or along a surface portion of one or more of the protrusions and/or voids.

Biocompatible compositions, in particular for the preparation of a biodegradable coating for medical articles, include a biocompatible thickening polymer and a chitosan derivative comprising D-glucosamine units of the following formula (I):

##STR00001##

wherein X is an alditolic or aldonic polyol residue of the following formula (II):

##STR00002##

wherein: R is CH.sub.2 or CO; R1 is hydrogen, a monosaccharide moiety or an oligosaccharide moiety; R2 is OH or NHCOCH.sub.3.

The present invention also relates to uses of the disclosed compositions, to a kit of parts including a composition in powder form and to a method for the preparation of a biocompatible composition in gel form.

The biodegradable coating shows a good and long-lasting adhesion to the surface of a medical article and allows to improve both the coating operations and the effectiveness in preventing any biofilm formation on the medical article.

Disclosed is a particulate water-absorbent resin composition containing at least one selected from the group consisting of a microporous inorganic material, silver, and a silver compound, and a polymer particle, in which the polymer particle contains an inorganic reducing agent.

The present disclosure relates to a multifunctional therapeutic biological material and preparation method thereof. The process steps of the preparation method are as follows: (1) preparing various three-dimensional micro/nano composite structure on the surface of a biomedical material by using femtosecond laser double pulses; (2) further preparing a nano-flower structure on the three-dimensional micro/nano composite structure by using hydrothermal synthesis method to construct a heterogeneous structure consisting of the three-dimensional micro/nano composite structure and the nano-flower structure; (3) putting the prepared heterogeneous structure into a mixed solution containing gold ions and platinum ions, and by using ultraviolet light reduction method, reducing in situ into gold-platinum bimetallic nanoparticles on the heterogeneous structure to obtain the multifunctional therapeutic biological material. The multifunctional therapeutic biological material provided by the present disclosure has excellent light-to-heat conversion characteristics, and it can promote bone regeneration, and has functions of tumor treatment and anti-bacterial infection.