The present disclosure relates to the technical field of bone repair and provides a berberine/mineralized collagen-based composite membrane as well as a preparation method and an application thereof. The composite membrane of the present disclosure includes a berberine nanofiber membrane and a mineralized collagen membrane disposed on a unilateral surface of the berberine nanofiber membrane. In the present disclosure, the mineralized collagen with biomimetic mineralization capacity is combined with a Chinese materia medica monomer, berberine, the resulting bilayer composite membrane has a better effect on promoting osteogenesis; in addition, a novel dosage form of berberine is constructed. The present disclosure employs an electrospinning method to prepare a berberine nanofiber membrane, the berberine nanofibers are received by the mineralized collagen membrane, or after the berberine nanofiber membrane is obtained, a mineralized collagen membrane is prepared by applying on the surface of the berberine nanofiber membrane.

Adhesive compositions are disclosed that include an octenidine salt, a resin system, a plasticizer, and a cidatrope. The dried adhesive compositions are substantially free of water and C.sub.2-C.sub.5 alcohols. The adhesive compositions disclosed are formulations that provide rapid and persistent antimicrobial activity and may be useful, for example, in wound dressings, surgical drapes, and medical tapes.

The present invention relates to methods of photocatalyzed bonding of compounds directly to surface metal oxides and the articles obtained therefrom. The methods for preparing an article having a compound bonded to a metal oxide comprise applying a compound that includes a photograftable moiety to the surface of the article; and applying light to the compound.

The patent disclosure covers antibiofilm compositions, wound dressings, cleaning methods and treatment methods. The antibiofilm composition is comprised of between about 0.05% (w/w) to about 0.20% (w/w) benzalkonium chloride; between about 0.20% (w/w) to about 0.50% (w/w) 3-(tri-methoxysilyl)propyldimethyl octadecyl ammonium chloride; between about 0.25% (w/w) to about 0.75% (w/w) phenoxyethanol and between about 98.55% (w/w) to about 99.5% (w/w) deionized water. Disclosed are wound dressings having a reservoir of the antibiofilm composition. In the field of inanimate surfaces, disclosed are methods to clean and clean and protect inanimate surfaces. In the field of animate surfaces, disclosed are methods for the treatment of nose, ear and skin/facial disorders associated with biofilms.

A splinting system that includes a curable splint member including layers of fiberglass cloth coated with a water curable resin, and a pad at least partially enveloping the layers of fiberglass cloth, the pad having an exterior surface and an antimicrobial coating applied to the exterior surface; and a metal foil pouch containing the curable splint member, the metal foil pouch including an exterior surface. The antimicrobial coating includes a silane quaternary ammonium ion or salt thereof. The silane quaternary ammonium ion or salt thereof is one or more of: 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium ion, 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium chloride, 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium ion, or 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium chloride. The antimicrobial coating can be applied to the curable splint member by applying a solution, which includes 0.1 percent and 10 percent by weight the silane quaternary ammonium ion or salt thereof and an isopropyl alcohol solvent, to the exterior surface of the pad.

Improved antimicrobial adhesive copolymer compositions for wound closure or surgical-site closure are provided. The antimicrobial adhesive copolymer compositions comprise cyanoacrylate-based tissue adhesive monomers and long-chain quaternary ammonium compounds (QUATs), or long-chain quaternary phosphonium compounds (QUPTs). The antimicrobial adhesive copolymer compositions offer advantages in wound closure or surgical-site closure with bactericidal and bacteriostatic effects on Gram-positive and Gram-negative organisms.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

An intravenous fluid bag comprising: a primary chamber configured to retain a liquid; a valve in fluid communication with the primary chamber, the valve including a housing, a spike element, and a seal, with the housing surrounding the seal, which surrounds the spike element; the spike element having a first end culminating in a tip, a second end having an inner conduit, and one or more through holes between the tip and the second end in fluid communication with the inner conduit forming part of a continuous liquid passageway in fluid communication with the primary chamber; the seal having a relaxed state preventing fluid flow through the valve, and the seal having a compressed state through which the through holes of the spike element extend allowing fluid flow from a source external the intravenous fluid bag, through the through holes, through the inner conduit, and into the primary chamber.

The disclosed technology relates to a wound dressing comprising an absorbent layer impregnated or coated with a composition comprising a chelating agent, an amphoteric surfactant, and an anionic surfactant. The invention further relates to methods and uses of the wound dressing.

The present disclosure relates to anti-microbial polymers comprising a polymerizable cyclic moiety which forms part of the backbone of the polymer.