A proportioning device includes a proportioning machine with a temperature-compensating conductivity sensor, a controller, and pump actuator. A fluid circuit is engageable with the pump actuator, has connections for a source of water and one or more medicament concentrates, and includes a mixing container. The controller is configured to mix contents of the mixing container at a first time and to sample fluid from the mixing container, to pass the samples from the mixing container through the temperature-compensating conductivity sensor at different points in time as the fluid flows from the mixing container. The controller is further configured to mix contents of the mixing container a second time if the conductivities differ by a predefined magnitude.

A peritoneal dialysis system includes first and second concentrate sources in selective fluid communication with a medical fluid pumping cassette, the first and second concentrate sources holding first and second peritoneal dialysis concentrates, respectively; a pump actuator configured to cause the medical fluid pumping cassette to pump the first and second concentrates; and a processor and memory configured to (i) determine a cumulative volume of at least one of the first or second peritoneal dialysis concentrates pumped from the medical fluid pumping cassette by the pump actuator, (ii) compare the cumulative volume to a threshold, and (iii) if the cumulative volume is outside of the threshold, modify a subsequent stroke volume of at least one of the first or second pump chambers actuated by the pump actuator in an attempt to cause an updated cumulative volume for the at least one peritoneal dialysis concentrate to be within the threshold.

An example peritoneal dialysis system is disclosed. The example peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine configured to remove ultrafiltrate (“UF”) from a patient and record how much UF has been removed. The APD machine operates according to a prescription to remove the UF. The system also includes a server in communication with the APD machine. The server analyzes the UF data to determine if the prescription is to be modified to compensate for changes to the patient's renal function or renal transport characteristics.

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to operate in a hybrid automated mode during a PD treatment. A processor in the control unit is configured to engage a pump during a fill phase of the PD cycle. The volume of fluid (e.g., dialysate) transferred to a patient line during the fill phase is monitored. After a dwell period, the pump is disengaged at the start of a drain phase of the PD cycle. Disengaging the pump can include: configuring valves of a disposable cassette to bypass the pump chambers of a disposable cassette; activating a bypass valve to shunt the patient line to a drain line; or moving a roller assembly of a peristaltic pump. The fluid transferred from the patient line to the drain line is monitored during the drain phase of the PD cycle.

A peritoneal dialysis system includes a cycler having one or more air pump; a slotted housing including a plurality of slots each having a first side and a second side, wherein each respective slot of the plurality of slots includes a first expandable bladder fixed to the first side, and wherein each respective slot of the plurality of slots is configured to receive a fluid supply bag between the first expandable bladder and the second side, and a heater housing sized to hold a second expandable bladder, and wherein the heater housing is configured to receive a fluid heater bag adjacent to the second expandable bladder, wherein the one or more air pump is in fluid communication with the respective first expandable bladders and the second expandable bladder; and a disposable set operable with the cycler.

A water purification apparatus (300) capable of being cleaned at a point of care, and methods for cleaning the water purification apparatus (300) at the point of care. The water purification apparatus (300) and the methods provide an efficient use of a heater (302) for heat disinfection the water purification apparatus (300), e.g. by recirculating heated fluid to further heat the fluid. Several different cleaning programs are provided that may be utilized for cleaning different parts of the water purification apparatus (300).

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a safety feature that is used to isolate individual fluid lines attached to a disposable cassette. The PD machine can include an interface for a disposable cassette, a plurality of safety mechanisms, and a processor. A plurality of fluid lines are connected to the disposable cassette, and each safety mechanism corresponds to a particular fluid line in the plurality of fluid lines. The processor is configured to detect a hazard condition, such as a loss of power to the PD machine or leak in the disposable cassette, and activate one or more safety mechanisms to isolate corresponding fluid lines connected to the disposable cassette. In one embodiment, the safety mechanisms are spring-loaded clamping mechanisms configured to compress a distensible tube connected to the fluid line. In another embodiment, the safety mechanisms include relay solenoids and/or check valves.

The present disclosure relates to methods for determining at least one treatment modality of a dialysis treatment of a specific patient depending on at least one value out of the group of values, a first value reflecting the overhydration (OH) of the patient, a second value reflecting the salinity or osmolarity of the patient, a third value reflecting the blood pressure of the patient, a fourth value reflecting the renal function of the patient, a fifth value reflecting a heart issue the patient, a sixth value reflecting hypotension of the patient, a seventh value reflecting vessel conditions, and an eighth value reflecting a total protein content of the patient. Herein, an algorithm or reference material is used. Furthermore, the disclosure relates to devices for executing this method and processing the results of the method.

Techniques and devices for filtering dialysis fluids, such as dialysis effluent, are described. For example, a filter device may be configured to filter peritoneal dialysis (PD) effluent draining from a patient during a PD process. The filter devices may include filters configured to filter materials, such as human cells, microorganisms, and/or other components from PD effluent. For instance, a filter device may be configured to be installed in-line in a drain circuit of a PD system using conventional tubing. The captured materials may be analyzed or otherwise processed to determine health characteristics of a patient and/or to capture stem cells. Other embodiments are described.

A method and apparatus for evaluating a condition of a water purification system (40, 110) comprising a water purification apparatus (110) arranged to output purified water through an outlet (128) and through at least one sterilizing grade filter (70a, 70b) of a line set (40) fluidly connected to the outlet (128), the method comprises: monitoring a flow rate (S1) correlated with the flow rate of the purified water flowing through the at least one sterilizing grade filter (70a, 70b); monitoring a pressure (S2) correlated with the pressure of the purified water flowing to the at least one sterilizing grade filter (70a, 70b); and evaluating (S3) a condition of the water purification system based on a relationship between the monitored flow rate and the monitored pressure.