A pneumatic system for a medical fluid machine operating a medical fluid cassette, the pneumatic system including an interface for supplying positive pneumatic pressure and negative pneumatic pressure to the medical fluid cassette; a source of positive pneumatic pressure; a source of negative pneumatic pressure; and a pneumatic pump including a first head and a second head, wherein the first head is dedicated to supplying positive pneumatic pressure to the positive pneumatic pressure source and the second head is dedicated to supplying negative pneumatic pressure to the negative pneumatic pressure source.

A hemodialysis machine comprising a fluid pathway for delivering a dialysate solution, wherein the fluid pathway comprises a pre-dialysis pathway and a post-dialysis pathway, a dialyser for dialysing patient's blood using the dialysate solution, the dialyser connected between the pre-dialysis pathway and the post-dialysis pathway, a first sensor system configured to sense a characteristic of the dialysate solution at a first location on the pre-dialysis pathway, a second sensor system configured to sense a characteristic of the dialysate solution at a second location on the post-dialysis pathway, and a control system configured to make a comparative analysis of the measurements taken by the first sensor and the second sensor for monitoring the composition of the dialysate solution.

The disclosed arterial chambers for hemodialysis may include a cap with a blood inlet port for conveying an intended patient's blood into the arterial chamber, an auxiliary port configured to provide fluid access to the arterial chamber, and a needleless access port configured to couple to a needleless syringe. The needleless access port may be configured for administering a substance to an interior of the arterial chamber from the needleless syringe and/or for withdrawing blood from the interior of the arterial chamber into the needleless syringe. Various tubing sets, hemodialysis systems, and other components, systems, and methods are also disclosed.

A mechanical kidney transplant designed may include a four modules designed to interconnect to clean blood. The first module may include a plurality of pump modules and a resin gel regeneration module, wherein the first module is operatively attached to a patient's iliac artery, iliac vein, and bladder. The second module may be operatively attached to the first module and may include storage and pump systems. The third module may be operatively attached to the first and fourth modules and may include a housing with ports for inflow/outflow of the blood and the physiologic resin gel between the first module and the fourth module. The fourth module may include at least one dialyzer fiber sized to accommodate a volume of blood flowing therethrough and an area surrounding the dialyzer fiber may be sized to accommodate a volume of a physiologic resin gel flowing counter current to the blood.

A medical device, such as a dialysis machine, may have multiple features and components that must be checked and attached prior to a treatment, and operators often lay tubing and other components on a surface after removing them from packaging. The system described herein provides a sterile work platform that is integrated with the medical device. In an example, the platform may be moveably coupled to the medical device. In a first position, the platform is positioned within or against the medical device, and, in a second position, the platform is extended from the medical device and disposed in a horizontal position. After the platform is extended to the second position, a surface of the platform is sterile and suitable to maintain aseptic technique for tubing and components placed on the platform. An information screen may be integrated into the platform and that provides information to an operator.

Provided are methods and arrangements wherein gases are removed via semipermeable membranes from aqueous, optionally complex biological substance mixtures, by dialysis in an aqueous medium. Special carrier molecules for gases are included in the dialysate that are regenerated in the dialysate circuit so that they can be used for further gas exchange cycles on the membrane.

An electro-osmosis pump system includes an inlet line through which a fluid is introduced, an outlet line through which the fluid is discharged, a first pump disposed between the inlet line and the outlet line and including a first housing in which a first operation fluid is disposed, a second pump disposed in parallel to the first pump between the inlet line and the outlet line and including a second housing in which a second operation fluid disposed, and a power supply configured to supply voltages to the first pump and the second pump. The first pump includes a first membrane, a 1A-th electrode, and a 2A-th electrode, the second pump includes a second membrane, a 1B-th electrode, and a 2B-th electrode, and the power supply supplies the voltage to the 1A-th electrode and the 2A-th electrode, and supplies the voltage to the 1B-th electrode and the 2B-th electrode.

A hollow fiber membrane module includes: a first hollow fiber membrane whose sieving coefficient for dextran having a molecular weight of not less than 300 kDa nor more than 1000 kDa is not less than 0.12 nor more than 0.28, wherein the first hollow fiber membrane adsorbs endotoxins.

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating target particles from elements of whole blood. The whole blood and capture particles are flowed through a microfluidic separation channel formed in a thermoplastic. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements of the blood and target particles to specific aggregation axes.

A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors, bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel and/or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.