The invention relates to devices, systems, and methods for recharging zirconium phosphate and/or zirconium oxide in reusable sorbent modules. The devices, systems, and methods provide for precision recharging of the zirconium phosphate and/or zirconium oxide to avoid the need of excess recharge solutions. The devices systems and methods also provide for calculation of the volumes of recharge solution needed for fully recharging the zirconium phosphate and zirconium oxide modules.

The hemodialysis system includes a closed loop dialysate flow path which includes a dialyzer and a reservoir for storing dialysate, and a closed loop blood flow path which passes through the dialyzer in the opposite direction as the dialysate flow path. In addition, the hemodialysis system includes pumps for pumping dialysate and blood through their respective flow paths, a flow sensor for measuring the flow rate of dialysate in the dialysate flow path, and a level sensor for measuring the level of dialysate in the dialysate reservoir. A processor is connected to the flow sensor, reservoir level sensor and pumps to provide a first closed loop control system including the processor, flow sensor and a first dialysate pump, and a second closed loop control system including the processor, level sensor and a second dialysate pump which enable the processor to initiate, monitor and maintain ultrafiltration.

The present invention concerns an anticoagulation fluid comprising 10-40 mM citrate and 0.1-4 mM phosphate. The anticoagulation fluid is to be used for regional citrate anticoagulation in an extracorporeal blood circuit. The anticoagulation fluid may be combined with at least one treatment fluid in a dialysis treatment, and it may be included in a system for regional citrate anticoagulation in an extracorporeal blood circuit.

A solid dialysis A agent is provided, which is to be used in preparing a bicarbonate dialysis fluid, wherein: the solid dialysis A agent contains glucose, acetic acid and an acetate salt; at least a part of a mixture of the acetic acid with the acetate salt is an alkali metal diacetate; and the acetic acid/acetate salt molar ratio is adjusted to 1/0.5 to 1/2. This solid dialysis A agent makes it possible to prepare a bicarbonate dialysis fluid which has a total acetate ion concentration of 2 to less than 6 mEq/L. Further, the dialysis A agent exhibits excellent stability of ingredients and a reduced acetic acid odor.

A toilet modified for disposal of dialysis waste includes a base, a bowl, a water supply port, and a dialysis drain port. In the dialysis drain port is a two piece air gap device that establishes a gap between ends of first and second drain tubes of a dialysis machine and a fluid level in the air gap. RO water and effluent from the dialysis machine enter the chamber of the air gap and mix, before being passed along a path from the dialysis drain port to the bowl of the toilet, where it can be dispelled in a sanitary manner in compliant with all pertinent codes and regulations.

Provided herein are methods for maintaining physiological levels of thiosulfate in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium thiosulfate to a subject undergoing hemodialysis.

A leakage detection method and system are used in blood treatment devices, such as a dialysis device used in continuous blood treatment/dialysis therapies, including renal replacement therapies.

An implantable or wearable kidney enclosure that is cylindrical, ovoid, or otherwise non-angular e.g., not rectangular or cuboid), having a circular or oval hemofilter that provides a blood flow pattern from an internal, central artery source radially outwards. Due to the efficient flow of the circular filter design, the enclosure can be made in a cylindrical low profile shape, resulting in a compact enclosure highly suitable for implantable and wearable dialysis applications.

A dialysis apparatus has a replenisher passage selectively connectable to an arterial side passage (pre-replenishment) or a venous side passage (post-replenishment) in a blood circuit. A supply side pressure sensor measures a pressure of a dialysate supply passage and a collection side pressure sensor measures a pressure of a dialysate collection passage. The connection passages each have one end communicating with the arterial side passage or the venous side passage of the blood circuit and another end connected to the dialysate collection passage. It is determined whether the replenisher passage is connected to the arterial side passage or the venous side passage, based on a differential pressure of pressures measured by the supply side pressure sensor and the collection side pressure sensor, in a state where a dialysate pump (liquid delivery device) causes dialysate to flow into the blood circuit from the replenisher passage.

A blood purification apparatus that includes a blood circuit including an arterial blood circuit and a venous blood circuit and that allows a patient's blood to extracorporeally circulate, with a blood purifier that is interposed between the arterial blood circuit and the venous blood circuit and purifies; a dialysate temporary chamber that temporarily stores dialysate received from a dialysate storage supported by a supporting unit; a substitution-fluid temporary chamber that temporarily stores substitution fluid received from a substitution-fluid storage supported by the supporting unit; a first dialysate introduction line through which the dialysate in the dialysate storage flows into the dialysate temporary chamber; and a substitution line through which the substitution fluid in the substitution-fluid storage flows into the substitution-fluid temporary chamber. The blood purification apparatus includes a dialysate transfer pump provided to the first dialysate introduction line and that transfers the dialysate in the dialysate storage to the dialysate temporary chamber, a substitution-fluid transfer pump provided to the substitution line and that transfers the substitution fluid in the substitution-fluid storage to the substitution-fluid temporary chamber, and a control unit that controls the dialysate transfer pump and the substitution-fluid transfer pump.