A cover member (36) that forms an end of a housing (26) of an oxygenator (10) has a recessed wall portion (88) recessed relative to a cover main body (74) further toward a side of a gas exchange unit (30) than an inner surface (74a). A pressure control hole (86) is formed through a main body (74) of the cover member (36), and a sampling port (90a) is disposed in the second recessed wall portion (88) to collect gas guided out from the gas exchange unit (30). The sampling port (90a) faces, at its inner opening portion (92), a second outlet side end face (31b) of the gas exchange unit (30).

A purger device for hollow fiber oxygenators, including a gas inlet, a gas outlet, and a fluid communication feature between the gas inlet and the gas outlet. The purger device further including an accumulation chamber having a variable volume plenum ported to the fluid communication feature, and a flow control unit configured to vary fluid communication patterns in the fluid communication feature and having a first operating condition and a second operating condition, wherein in the first operating condition the flow control unit enables a fluid communication between the gas inlet and gas outlet, and wherein in the second operating condition the flow control unit enables a fluid communication between the gas inlet and the variable volume plenum of the accumulation chamber.

A double-lumen percutaneous femoral cannula for extracorporeal membrane oxygenation (ECMO) is an apparatus that is used to perform an ECMO procedure in non-ideal conditions. The apparatus may include at least one first cannula and at least one second cannula of different sizes that are arranged to form a single structure. By providing a single structure instead of several separate components, the apparatus makes the insertion of the apparatus easier and reduces the risk of the apparatus dislodging while the patient is being transported. The at least one first cannula and the at least one second cannula are preferably elongated tubular structures designed to prevent the recirculation of oxygenated blood. The at least one first cannula is designed to enable the aspiration of deoxygenated blood, while the at least one second cannula is designed to enable the pumping of oxygenated blood back into the body.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

Disclosed herein are methods of treating venous thrombosis and vascular inflammation through administration of carbon monoxide and/or a carbon monoxide releasing molecule. Also disclosed herein are devices capable of releasing carbon monoxide for the purpose of treating microvascular, arterial and venous thromboembolism and/or inflammation.

The invention relates to an oxygenator for gas exchange in the bloodstream, comprising a housing, a first interior chamber for blood arranged in the housing, a second interior chamber for gas arranged in the housing, and a membrane separating the interior chambers. According to the invention, the membrane has a silicone layer and a reinforcing structure reinforcing the silicone layer.

A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

An exchanger for medical use comprises: a box-like body having a base, an upper end, a peripheral wall that delimits a heat exchange chamber; the body having: a first aperture from which a fluid to be thermo-regulated enters and a first exit of the thermo-regulated fluid; a second delivery aperture of a thermo-regulator fluid and a second exit of the thermo-regulated fluid; a heat exchange element that exchanges heat by lapping, housed in the exchange chamber and held between two holding elements, dividing the exchange chamber into a zone where the thermo-regulator fluid flows and a zone where the fluid to be thermo-regulated flows, which are fluid-dynamically separated from each other; a collection compartment to collect the air separated from the fluid to be thermo-regulated, obtained in the opposite end, connected to the thermo-regulation chamber and equipped with an aperture toward the outside; the box-like body has a second housing chamber for a pumping group, connected with the heat exchange chamber.

The invention is a cooling unit for a heat exchanger, which preferably is a heat exchanger integrated in an oxygenator for the purpose of controlling the temperature of blood conveyed in an extracorporeal blood circuit. The cooling unit has a reservoir in which a liquid is stored, a reaction vessel comprises a reactant and which, in conjunction with the liquid, is able to initiate an endothermal reaction. A fluidic access is generated between the reservoir and the reaction vessel. A fluid line extends at least in part inside the reaction vessel which has an inlet line and outlet line, which are each connectable or connected in a fluid-tight manner to a hose system of the heat exchanger, which together with the hose system of the heat exchanger, provides least part of a fluid circuit.

An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.