An artificial lung in a circulation apparatus can be monitored and be maintained in a safe condition without manual assistance. As an extracorporeal circulation mode starts, it is determined first whether or not gas exchange of the artificial lung is carried out within a normal range, based on oxygen concentration which is detected by an oxygen sensor positioned at a downstream place in the artificial lung. If the gas exchange is carried out within the normal range, an estimated value for gas supply volume of a gas blender is maintained. When oxygen concentration exceeding the normal range is detected, the gas blender is controlled so as to revise the gas supply volume downward. In addition, when oxygen concentration falls below the normal range, the gas blender is controlled so as to revise the gas supply volume upward.

In manufacturing an oxygenator (10), an intermediate spacer (18) is arranged between an inner cylinder unit (13) configured by winding a first hollow fiber membrane (14a) and an outer cylinder unit (15) configured by winding a second hollow fiber membrane (16a) so that a first gap (100a) is formed between one end portions of the inner cylinder unit (13) and the outer cylinder unit (15), and a first partition section (62a) is inserted into the first gap (100a). A first end portion (18a) of the intermediate spacer (18) is located at a region which does not overlap the first partition section (62a) in a radial direction. The intermediate spacer (18) independently supports the outer cylinder unit (15) in a state in which a gap (Sa) is formed between an inner peripheral surface of the intermediate spacer (18) and an outer peripheral surface of the inner cylinder unit (13).

An artificial lung 100 has a filling portion 110 that communicates with an inlet port 101 and an outlet port 102 for blood and is filled with blood, a heat exchange portion 160 that includes a bundle of a plurality of hollow fibers 163 for heat exchange and is provided inside the filling portion, a gas exchange portion 170 that includes a bundle of a plurality of hollow fibers 173 for gas exchange and is provided inside the filling portion to be adjacent to the heat exchange portion, and a porous member 180 that is disposed in a gap 190 between the heat exchange portion and the gas exchange portion. A volume within the housing occupied by a wall of the porous member correspondingly reduces a priming volume within the housing available for conveying the blood (i.e., a bulk volume of the porous member partially blocks or fills the gap.

Perfusion systems and methods are provided for increasing peripheral blood flow to reduce limb ischemia, in which an extracorporeal pump having a controller, and catheter/tubing set, employed alone or in conjunction with an interventional or circulatory assist device, withdraws blood from a patient's vasculature and reintroduces that blood at another location within the patient's vasculature at a controlled local pressure or flow rate, without interfering with operation of the interventional or circulatory assist device or surgical intervention.

Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.

An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.

A carrying device for a portable gas exchange device has at least one first holding strap which is designed to be worn around a torso of a patient, thereby allowing the carrying device to be supported on the patient. The carrying device further includes a fastener which is designed to fasten a portable gas exchange device. Also provided is a carrying system which consists of a carrying device and a gas exchange device.

The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions within a subject and to related methods. More particularly, the invention relates to a cytopheretic cartridge that includes a housing and, disposed within the housing, a solid support capable of sequestering activated leukocytes and/or platelets.

A method controls a device for extracorporeal blood gas exchange. The device has a membrane as a gas-liquid barrier between a bloodstream and a gas stream. The membrane further makes possible a passing over of the carbon dioxide content from the bloodstream into the gas stream. The device has at least one actuator. A change in a value of an operating parameter of the actuator brings about a change in a value of the carbon dioxide content that passes over from the bloodstream into the gas stream. The method further includes providing breathing gas information that indicates a carbon dioxide concentration in breathing gas and providing a control signal, which indicates a request for setting a value of the operating parameter and changing of the value of the operating parameter as a function of the carbon dioxide concentration in the breathing gas.

A total artificial heart for a mammalian cardiovascular system is provided. The total artificial heart has a pump casing including an outer housing and an integral hollow support shaft extending therethrough. The casing defines a first flow path within the outer housing about an exterior of the hollow support shaft and a separate second flow path extending within the hollow support shaft. An annular impeller is housed within the outer housing of the casing for rotation about the hollow support shaft to provide a centrifugal flow pump in the first flow path, and an axial flow impeller is housed within the hollow support shaft of the casing for forming an axial flow pump in the second flow path.