A system for lung assist includes a plurality of fiber bundle sections. Each of the fiber bundle sections includes a fiber bundle housing defining a fiber bundle compartment therein and a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers configured to permit diffusion of gas between blood and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. Each fiber bundle is different in at least one property from each other fiber bundle. The fiber bundle housing further includes a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, and a blood outlet in fluid connection with a first end of the fiber bundle. The fiber bundle housing also includes a first interface. The system further includes a base section including a housing including a pressurizing compartment, a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit in fluid connection with the pressurizing compartment at a first end thereof via which pressurized fluid exits the pressurizing compartment. The base further includes a second interface adapted to form a releasable, sealing connection with the first interface of one of the plurality of fiber bundle sections. A second end of the conduit is placed in fluid connection with a second end of the fiber bundle when the fiber bundle section is connected to the base section via the first interface and the second interface.

The invention relates to a method for producing a device for material exchange between two mediums, in which at least one mat of semipermeable hollow fibres (3) is wound onto a winding core (2), which has at least one core opening (2a) in its outer surface for a first in- or out-flowing medium, and the winding core (2) is arranged in an axially extending housing (1) having at least one housing opening (1a) for the first in- or out-flowing medium, and the axial end regions of the housing (1) are sealed by an adhesive (4) arranged around the hollow fibres (3), wherein at least one chamber region (5) surrounding the hollow fibres (3) is formed via the adhesion between the axial end regions (1b, 1c) of the housing (1) and between the winding core (2) and the housing (1), through which chamber region the first medium can flow via the core opening (2a) and the housing opening (1a), wherein the axial distance between the core opening (2a) and the housing opening (1a) is adjusted to a desired value of multiple possible values via the axial shifting of the winding core (2) relative to the hollow fibre winding (3) arranged around the winding core (2) and relative to the housing (1), and the hollow fibres (3) are adhered to the side of the housing (1) near to the housing opening (1a) in a region between the axial end surface of the housing and the housing opening (1a), and the hollow fibres (3) are adhered to the side of the housing (1) near to the core opening (2a) in a region between the axial end surface of the housing and the core opening (2a). The invention also relates to a number of multiple devices for material exchange between two mediums, wherein all devices comprise at least identical housings (1) and winding cores (2) that are identical at least in regions.

Systems and methods for regulating fluid volume from an isolated cardiac circuit during cardiopulmonary bypass surgery are described. In one embodiment, a system in accordance with the present technology can include a pressure-regulated volume control unit configured to regulate a cardiac circuit volume based on a measured return pressure detected at an outflow from an internal heart portion of cardiac circuit. The system can also include a first pressure sensor configured to detect the measured return pressure.

The present invention relates to a blood oxygenator device comprising an equilibration-measurement unit for determining the concentration of an inhalational anesthetic in the blood of a patient, a method of manufacturing such a blood oxygenator device and methods of using such a blood oxygenator device.

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart.

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.

A hollow fiber membrane bundle configured to be used in an artificial lung and comprised of integrated hollow fiber membranes 31 has hollow portions through which a fluid passes. The hollow fiber membrane bundle is shaped as a cylinder body. In addition, the hollow fiber membrane 31 is tilted with respect to a central axis O of the cylinder body, is wound around the central axis O of the cylinder body, and satisfies the following conditions. An inner diameter d.sub.1 of the hollow fiber membrane 31 is equal to or smaller than 150 m, a tilt angle with respect to the central axis O of the cylinder body of the hollow fiber membrane 31 is equal to or smaller than 60, and a ratio D.sub.1/L of an outer diameter D.sub.1 of the cylinder body to a length L of the cylinder body is equal to or greater than 0.4.

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.

Adaptors, cannulas, caps, tube couplers, and systems thereof provide endovascular access through an established ECLS system. Adaptors having curved or angled shafts navigate right angle side ports of standard bypass cannulas and permit hemostatic introduction and direction of an intervention device to the axial flow path of the cannula lumen and bypass system. A modified cannula having an angled side port is also provided for use as an arterial cannula. A cap having an occluding surface may be inserted into the angled side port to prevent blood from stagnating in the angled side port. A tube coupler is also provided having an access port, such as an angled access port, and may be spliced into an established bypass system for vascular access point. Multiple couplers can be used to provide multiple access points. The adaptors and occlusive cap are interchangeable with each other and with secondary circuits.

Adaptors, cannulas, caps, tube couplers, and systems thereof provide endovascular access through an established ECLS system. Adaptors having curved or angled shafts navigate right angle side ports of standard bypass cannulas and permit hemostatic introduction and direction of an intervention device to the axial flow path of the cannula lumen and bypass system. A modified cannula having an angled side port is also provided for use as an arterial cannula. A cap having an occluding surface may be inserted into the angled side port to prevent blood from stagnating in the angled side port. A tube coupler is also provided having an access port, such as an angled access port, and may be spliced into an established bypass system for vascular access point. Multiple couplers can be used to provide multiple access points. The adaptors and occlusive cap are interchangeable with each other and with secondary circuits.