A dual lumen drainage cannula configured for use in a VA ECMO system includes a first drainage tube having a proximal end, a distal end, and at least one aperture in at least one wall of the first drainage tube proximate to the distal end of the first drainage tube, and a second drainage tube having a proximal end, a distal end, and at least one aperture in at least one wall of the second drainage tube proximate to the distal end of the second drainage tube. The first drainage tube passes through the second drainage tube. The dual lumen drainage cannula also includes a sleeve positioned adjacent to an interior wall of the second drainage tube. The sleeve is formed of a flexible material so as to be expandable and collapsible within the second drainage tube.

This invention is directed to system and methods for the oxygenation of the blood of a patient, comprising an extracorporeal blood circulation path adapted to be coupled to the patient's vascular system, and comprising apparatus for oxygenating blood flowing therein and withdrawing CO2 therefrom, wherein the flow rate of blood flowing in said extracorporeal blood circulation path does not exceed of the patient's blood flow. The extracorporeal blood circulation path preferably comprise a cartridge including an oxygenator and at least one cannula.

Systems are provided including a sheath and cannula combination device for permitting a user to select between directing blood flow through a first cannula portion of the combination device in a cannula mode and enabling an interventional medical procedure through a second sheath portion of the combination device in a sheath mode, or performing both modes simultaneously. The combination device may include a connector hub configured to auto-washout stasis regions of blood within the first cannula portion. The system may include a series of removable caps for temporarily sealing the first and/or second portions of the combination device, such that the user may seamlessly select when to use the combination device in the cannula mode, the sheath mode, both the cannula and sheath modes simultaneously, or neither the cannula mode nor the sheath mode.

A method for controlling carbon dioxide [CO2] removal in a device for extracorporeal blood gas exchange is disclosed. The device comprises an oxygenator including a membrane acting as a gas-liquid barrier enabling CO2 transfer between a bloodstream and a sweep gas flow through the oxygenator. The method comprises the steps of measuring a pre-oxygenator fraction of CO2 [FCO2.sub.in] in the sweep gas flow upstream of the oxygenator, measuring a pre-oxygenator sweep gas flow rate ({dot over (V)}.sub.in) of the sweep gas flow upstream of the oxygenator, measuring a post-oxygenator fraction of CO2 [FCO2.sub.out] in the sweep gas flow downstream of the oxygenator, measuring a post-oxygenator sweep gas flow rate ({dot over (V)}.sub.out) of the sweep gas flow downstream of the oxygenator, and calculating a net CO2 exchange [{dot over (V)}CO2.sub.net] over the membrane based on measured FCO2.sub.in, {dot over (V)}.sub.in, FCO2.sub.out and {dot over (V)}.sub.out.

A medical device includes an elongated member configured to be inserted into a vessel of a patient. The elongated member includes a permeable membrane that defines a wall of the elongated member and a flow channel within the wall. The permeable membrane defines nanopores extending from an exterior surface of the permeable membrane to tire flow channel. Idle nanopores are configured to enable diffusion of a pressurized gas from out of the flow channel and. into a fluid within the vessel. The nanopores are configured to form gas nanobubbles at the exterior surface of the permeable membrane as the pressurized gas diffuses out from the flow channel and into the fluid within the vessel.

A system configured to enclose a premature fetus within an extracorporeal environment to promote growth of the fetus and increase viability of the fetus. The system includes a device for measuring oxygen saturation.

A system (100; 1) for analysing gas concentrations before and after a point of gas exchange (P.sub.GE; 3, 23) is disclosed. The system (100; 1) comprises a gas inlet line (101; 11, 33a) for conveying a flow of an input gas mixture towards the point of gas exchange (P.sub.GE; 3, 23), a gas outlet line (103; 13, 33b) for conveying a flow of an output gas mixture away from the point of gas exchange (P.sub.GE; 3, 23), and a gas analyser (105) that is connected to both the gas inlet line (101; 11, 33a) and the gas outline line (103; 13, 33b) and configured to sequentially receive and analyse gas samples from the gas inlet line (101; 11, 33a) and the gas outlet line (103; 13, 33b) in order to determine a presence of a specific gas in the input gas mixture and the output gas mixture.

Methods and apparatus for controlling a flow rate of an oxygenator device are described. The method includes receiving a first temperature associated with a blower of the oxygenator device, wherein the first temperature is sensed by a temperature sensor of the oxygenator device, and adjusting a flow rate of oxygen provided to a blood oxygenator by the blower based, at least in part, on the first temperature.

An oxygenation device for use with extracorporeal blood circulation is disclosed. The device includes an oxygenator housing having a blood inlet end cap having a blood inlet opening, a blood outlet end cap having a blood outlet opening, and a gas collector housing between the blood inlet opening and the blood outlet opening. The gas collector housing defines a gas compartment having a gas inlet chamber with a gas inlet port and a gas outlet chamber with a gas outlet port. Heating devices are disposed against the gas collector housing and include a first heating device in the gas inlet chamber and a second heating device in the gas outlet chamber. During operation of the oxygenation device, the heating devices heat the gas compartment.

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.