A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. Elastic waves may be generated at a pump that introduces (e.g., for fill cycles) or withdraws (e.g., for drain cycles) the solution into/out of the patient line. For example, when the solution is introduced or withdrawn suddenly, elastic waves travel distally down the patient line until they encounter the occlusion, and are then reflected back (e.g., toward the pressure sensor).

Disclosed herein are devices and methods related to UV disinfection of a transfer catheter during peritoneal dialysis. The transfer catheter comprises a first and second end, the second end comprising a transfer valve. The transfer valve body comprises an inlet, outlet, and a flush hole. The valve core comprises a notch configured to allow fluid flow between the various flow paths. The valve core and body are positioned off axis with respect to the fluid flow path. The transfer catheter can allow for a small volume kill zone, which can minimize the amount of UV required to disinfect the catheter.

The present invention relates to a device for identifying the connection status between a patient catheter and a cassette system having flexible tubing assembly, which is intended to be used in a dialysis machine, wherein the device comprises the cassette system having flexible tubing assembly and an electrical circuit, which is disposed on the cassette system having flexible tubing assembly as well as on the patient catheter, and wherein the device furthermore comprises a measuring device for measuring at least one electrical property of the electrical circuit, which depends on said connection status.

A fluid extraction implantable system shaped and sized to be implanted in a patient, including: a fluid extraction chamber having a flat and thin shape connected to a draining tube and including at least one external flat surface, wherein the at least one external flat surface is configured to be attached to a tissue surface when a negative pressure is applied on the draining tube, wherein the chamber extracts fluids from the tissue by applying the negative pressure through the flat surface on the attached tissue surface.

A direct sodium removal (“DSR”) infusate regimen and methods of use are provided for removing sodium and reducing fluid overload in patients with severe renal dysfunction and/or heart failure, in which a patient has at least a first DSR session with a first DSR infusate having no or low sodium that is instilled into a patient's peritoneal cavity for a first dwell period to cause sodium and excess fluid to migrate to the patient's peritoneal cavity, and thereafter, the patient may undergo conventional dialysis to rebalance the patient's fluid and sodium levels.

The present disclosure provides a method for hemodialysis of blood, comprising providing a hemodialysis catheter having a low recirculation distal tip, a first and a second extension tubes that are configured to be connected to a dialysis machine, providing a hemodialysis machine with an arterial patient connector and a venous patient connector; conducting hemodialysis with the first extension tube connects to the arterial patient connector of the dialysis machine, and the second extension tube connects to the venous patient connector of the dialysis machine; and periodically reversing the first and second extension tubes connections to the arterial and venous patient connectors of the dialysis machine in a subsequent hemodialysis. The present disclosure also provides a hemodialysis catheter, comprising a switchable connection indicator indicating connection to arterial or venous flow path. The switchable connection indicator can be integrated with a clamp.

A personalized chronic care apparatus is disclosed herein. An example apparatus includes a server operating over a network, software stored on the server, and a compliance entry feature configured to receive compliance information related to a patient. The software includes an automated learning method for creating an overall kidney maintenance plan that specifies one or more controllable variables as actions performed by the patient to prevent or reduce complications associated with chronic kidney disease (CKD). The automated learning method is configured to perform an evaluation to determine whether a selected controllable variable is to be included in the overall kidney maintenance plan by confirming when (i) a worsening of kidney function is not determined between first evaluation data and second evaluation data over a testing period, and (ii) the compliance information provides a confirmation that the selected controllable variable was modified over the testing period.

Systems and methods of disinfection of catheter connections are provided. A transfer catheter connector can include a UV-transparent window at its distal end and a sealing plunger proximal to the UV-transparent window. A solution set connector can be inserted inside a portion of the transfer catheter connector to connect a solution set and transfer catheter. The solution set connector comprises a lumen covered by a leading membrane surface; a sealing surface configured to sealingly engage the window surface, and a piercing member configured to pierce the membrane surface. The sealing plunger, membrane surface, and window define a disinfection zone. The connectors can be connected in a disinfection position configuration in which flow is not permitted between the catheters and the connectors are irradiated with UV light. After disinfection, the connectors are advanced to a flow position in which the piercing member pierces the membrane surface, enabling flow between the catheters.

A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

An assembly comprises a manifold configured to couple to a medical fluid cassette and a multi-lumen tube comprising a plurality of lumens within an outer wall of the multi-lumen tube. The manifold has a plurality of fluid connection ports and can be connected to the multi-lumen tube (e.g., via an adapter).