A method for treating sickle cell disease comprises removing blood from a patient with sickle cell disease, treating the removed blood to decrease the fraction of sickle-prone cells in the removed blood, and reintroducing the treated blood back into the patient. The treated blood that is reintroduced back into the patient has a reduced number of sickle-prone red blood cells when compared to the blood removed from the patient. In one version, the treatment of the blood includes inducing sickling of the red blood cells prone to sickle and then separating those sickled red blood cells from the blood before reintroducing the blood back into the patient.

A system and method to deliver a medicant to a premature fetus in an extracorporeal environment. Exemplary medicants include at least one selected from stem cells and modified genes. The system can include a chamber to enclose the fetus, a first fluid circuit including a source of a liquid, a pump configured to move the liquid, and a second fluid circuit including an oxygenator configured to transfer oxygen to the fetus. The umbilical cord of the fetus is connected to the second fluid circuit by attaching a first cannula connected to a vein of the umbilical cord, attaching a second cannula to a first artery of the umbilical cord, attaching a third cannula to a second artery of the umbilical cord, and connecting one or more of the first, second and third cannulae to the oxygenator via an oxygenation circuit.

An HLM system may include a controller and a plurality of venous sensors disposed along a venous pathway. Upon activation of the HLM system, the controller may be configured to suppress alarms associated with sensors until blood is detected within the venous pathway by a venous blood gas sensor. The controller may be configured to start a bypass timer upon detection of blood within the venous pathway. A method of bypassing a patient's heart with an HLM system may include activating the HLM system, coupling a venous pathway of the HLM system to at least one venous portion of a patient's vasculature; coupling an arterial pathway of the HLM system to at least one arterial portion of the patient's vasculature; and suppressing alarms associated with sensors until blood is detected within the venous pathway by the venous blood gas sensor.

A monitoring apparatus is to be applied to an assisted circulation apparatus, the assisted circulation apparatus being connected to a living body, transferring blood removed from the living body to a membrane lung by a blood transfer pump, and gas-exchanging and oxygenating the blood in the membrane lung in parallel with a native lung, and the monitoring apparatus includes a calculation unit that calculates a blood gas-exchanging state index indicating a gas-exchanging state of blood by the assisted circulation apparatus.

A method for onsite hemorrhage control in trauma patients using a portable rapid autotransfusion device can involve recovering a first portion of patient blood from an extravascular space into a fluid reservoir of the device. A negative internal pressure can be applied to the blood. The blood can be conditioned, such as by oxygenating and removing carbon dioxide. The conditioned blood can be returned to the patient intravenously at a rate that matches the rate of blood recovery, ensuring that the net volume of returned blood is maintained substantially equal to the net volume of removed blood.

A CRRT apparatus comprising a control unit configured to execute a flow-rate setup procedure by receiving a patient prescription comprising clinical prescription parameters, by allowing entry of a set value for a prescribed dialysis dose (D.sub.set) to be delivered, and of a target value for a parameter (nNBL; Cp.sub.HCO3_PAT) indicative of a steady state acid-base balance in the blood of the patient who has to undergo a CRRT blood treatment, and by determining operating parameters calculating a set value of relevant fluid flow rates including one or more of a fluid flow rate (Q.sub.cit) through the anticoagulant infusion line, a fluid flow rate (Q.sub.PBP) through the PBP infusion line, a fluid flow rate (Q.sub.rep.pre) through the pre-dilution infusion line, a fluid flow rate (Q.sub.rep.post) through the post-dilution infusion line, a fluid flow rate (Q.sub.HCO3) through the post-dilution bicarbonate infusion line, a fluid flow rate (Q.sub.ca) through the ion balancing infusion line, a blood fluid flow rate (Q.sub.b) through the extracorporeal blood circuit, a fluid flow rate (Q.sub.dial) through the dialysis liquid supply line, and a fluid flow rate (Q.sub.eff) through the effluent fluid line, wherein calculating the set value of the fluid flow rates is based at least on the set value of the prescribed dialysis dose (D.sub.set) and on the target value for the parameter (nNBL; Cp.sub.HCO3_PAT) indicative of a steady state acid-base balance in the blood.

A method for predicting a blood pump state, characterized in that a pump device is driven by a motor, includes collecting an average phase current of each phase of the motor in a current cycle, determining whether the average phase current of each phase of the motor is stable, determining whether the average phase current of each phase of the motor changes consistently in response to determining that the average phase current of each phase of the motor is unstable, determining whether the average phase current of each phase of the motor changes shows a cyclic change in response to determining that the average phase current of each phase of the motor changes consistently, and determining that a blood pump of the pump device is abnormal in response to determining that the average phase current of each phase of the motor changes shows the cyclic change.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

A crossflow filter includes a rigid cylindrical inner wall and a rigid cylindrical outer wall inner with an inelastic filter membrane positioned therebetween defining a retentate channel inside the filter membrane and a permeate channel outside the filter membrane. Further, the filter includes transition channels shaped and connected to the inner and outer walls to deliver a flow of fluid from an inlet port to the retentate channel and to capture flow flowing longitudinally along the cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.