A quantum dot light-emitting device, a display apparatus, and a manufacturing method are provided. The quantum dot light-emitting device includes a base substrate and a plurality of sub-pixels having different light-emitting colors located on one side of the base substrate. Each sub-pixel includes a first electrode; a quantum dot light-emitting portion, the quantum dot light-emitting portion being located on the side of the first electrode facing away from the base substrate; an electrical response portion, the electrical response portion being located between the first electrode and the quantum dot light-emitting portion and having a conjugated polymer or a reaction product of the conjugated polymer; and a second electrode, the second electrode being located on the side of the quantum dot light-emitting portion facing away from the electrical response portion.