A pressure regulation system for discharging a liquid having a predetermined liquid pressure from a liquid opening, including an elastic bag having a liquid phase and a gas phase, where the liquid opening in an operational position of the elastic bag is formed in the lower area of the elastic bag, at least two push elements, at least one drive unit and a control unit. The elastic bag has a gas opening, which extends into the gas phase. The pressure regulation system has a ventilation unit, which is connected to the control unit for communication and which connects to the gas opening of the elastic bag. The ventilation unit regulates the liquid pressure of the liquid discharged through the liquid opening by means of a gas supply into the elastic bag and/or a gas discharge from the elastic bag.

A catheter with an electrode assembly has a functional electrode located at a first position on the electrode assembly and a shunting electrode located proximal to the first position. Irrigation fluid carried by the catheter may be electrically coupled with a patient's blood through the shunting electrode. The shunting electrode may be used to reduce noise in an electrocardiogram signal that results from the pump used to supply the irrigation fluid.

A synchronized automated bronchial lavage aspiration apparatus synchronizes with ventilator inspiration and expiration cycles to clear a patient's airway of stagnant secretion automatically. Synchronized and automatic instillation of saline prior to aspiration suppresses bacteria in the airway and suctioning during exhalation drains the airway of sputum.

The disclosed apparatus, system and method may include at least a surgical fluid container that includes a fluid reservoir capable of containing the surgical fluid and a gas pressure pocket applied to the surgical fluid therewithin; a first external port extending from outside the fluid reservoir into fluid communication with the surgical fluid within the fluid reservoir; and a second external port extending directly from outside the fluid reservoir into the gas pressure pocket.

Pressure control unit for an ophthalmic irrigation/aspiration system having a chamber with an upper part for storing air and a lower part for storing a surgical fluid to be irrigated or aspirated, the pressure control unit including a negative pressure source, a positive pressure source and an adjustable valve arrangement. The adjustable valve arrangement includes a vacuum port connected to the negative pressure source and a pressure port connected to the positive pressure source. The adjustable valve arrangement also includes a main port in controllable fluid communication with the vacuum port and the pressure port and the main port is connected to an upper part of the chamber.

Renal and urine collection system interventions are provided that improve kidney function by manipulating pressures and/or infusing therapeutic agents in the renal pelvis of the kidney or kidneys. Setting a vacuum and/or infusing therapeutic agents in the renal pelvis results in increased glomerular filtration rate, general solute clearance, and free water excretion via the kidney through the urinary tract and is useful for treatment of CHF, ADHF, AKI, CKD, and many other conditions characterized by fluid overload by reducing fluid buildup. The fluid drawn from the renal pelvis or pelvises is delivered to an external or implanted reservoir or to the bladder using flow manipulation mechanism such as one-way valves, occlusion balloons, multi-lumen catheters, and other mechanisms. Pumps are provided for use in establishing the vacuum pressures that are either manual or motorized.

Methods of treating a medical condition in a patient include performing a lipectomy of visceral fat to remove a quantity of the visceral fat from the subject. The removal of visceral fat treats the medical condition such that the subject experiences at least a reduction of symptoms of the medical condition.

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

Systems, methods, and apparatuses for irrigating a tissue site are described. The system can include a tissue interface and a sealing member configured to be placed over the tissue site to form a sealed space, and a negative-pressure source fluidly coupled to the sealed space. The system includes an irrigation valve having a housing, a piston disposed in the housing, a fluid inlet to fluidly couple a fluid inlet chamber to a fluid source, and a fluid outlet to fluidly couple a fluid outlet chamber to the sealed space. A piston passage extends through the piston and fluidly couples the fluid inlet chamber and the fluid outlet chamber, and a biasing member is coupled to the piston to bias the irrigation valve to a closed position. The negative-pressure source is configured to move the piston between the closed position and an open position to draw fluid to the sealed space.

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.