An instrument having a dosing unit connected to a handle or housing of instrument. The dosing unit may include a reusable actuator with a drive unit and a single-use cartridge. The Cartridge may have a cylinder and a piston, and may be filled by a user prior to the intervention or may be prefilled by the manufacturer. The dosing unit is brought into an open position offset from housing by, for example, operating a latch slider and pulling the dosing unit in a proximal direction. After insertion of the cartridge, the dosing unit may be moved toward housing and the latched slider will lock the dosing unit into a closed position.

A system for performing irrigation of a body cavity includes a reservoir containing an irrigation liquid, a catheter and a controller. The catheter is configured to be at least partially inserted into the body cavity and has a flushing passage, a drain passage and a retention balloon. A waste drain valve is in fluid communication with the drain passage of the catheter and is movable between a closed configuration, where waste is retained within the drain passage, and an open configuration where waste flows through the drain passage. The controller is in fluid communication with the reservoir and the catheter, and has a pump and a valve assembly. The valve assembly is changeable between configurations where, when the pump is actuated, irrigation liquid is pumped from the reservoir to the retention balloon, from the reservoir to the flushing passage of the catheter and from the retention balloon to the reservoir.

The invention relates to a method for filling an inflatable catheter balloon of a device for transanally introducing an infusion into the rectum or colon of a patient by means of a filling device, wherein a fill volume or a filling pressure prevailing in the catheter balloon is increased in two or more steps until there occurs a gradual, user-controllable, pneumatically initiated expansion of portions of the bowel wall, thus triggering a coordinated defecation reflex, wherein the timing and intensity of the triggering stimulus can be determined to the greatest possible extent by the user.

An appliance is provided for negative-pressure therapy of wounds on the human or animal body in which, on the one hand, a substance is delivered to a wound bed (W) and, on the other hand, fluids, in particular an exudate and the delivered substance, are aspirated from the wound bed by negative pressure. The appliance has a suction pump housing, with a suction pump arranged therein for aspirating the fluids from the wound bed (W), and a fluid collection container for collecting the aspirated fluids. Moreover, the appliance has a first measuring device and a second measuring device. The first measuring device serves to determine the quantity of the aspirated fluids, and the second measuring device serves to determine the quantity of the substance delivered to the body.

A rectal drainage appliance is disclosed comprising a tubular element having an inflatable balloon at a distal end for anchoring the appliance in the rectum. The appliance includes one or more of: (i) first and second auxiliary lumens communicating with the inflatable balloon to provide independent inflation and pressure monitoring paths coupled to the balloon; (ii) a pressure state indicator defined by a mechanical element configured to flip between first and second states or shapes responsive to sensed pressure; and (iii) a collapsible auxiliary lumen larger than the inflation lumen, and configured to permit admission of irrigation fluid. The pressure state indicator may also be used in intestinal drains.

A cannula ingress system may include a tip stabilization mechanism having a tip stabilization mechanism distal end and a tip stabilization mechanism proximal end, a fixation mechanism, a hypodermic tube having a hypodermic tube distal end and a hypos dermic tube proximal end, and a tip having a tip distal end and a tip proximal end. The tip may be disposed within the hypodermic tube wherein the tip distal end extends from the hypodermic tube distal end. The fixation mechanism may be disposed within a fixation mechanism channel of the tip stabilization mechanism. The tip stabilization mechanism may be disposed over the tip and the hypodermic tube distal end.

An apparatus for cooling tissue or a fluid for an elongate medical device comprising an elongate shaft extending along a longitudinal axis and comprising a shaft proximal end and a shaft distal end; a support structure located at the shaft distal end, where the support structure is expandable from a contracted state to an expanded state, and a plurality of thermoelectric elements, wherein the thermoelectric elements are located on the support structure. A medical device comprising a first catheter end shape, a second catheter end shape located distally with respect to the first catheter end shape, a support structure that extends between the first and the second catheter end shape, and a plurality of thermoelectric elements. A system for cooling a tissue or a fluid for an elongate medical device, comprising a plurality of thermoelectric elements, a thermocouple, an electronic control unit (ECU).

In one aspect, the disclosure relates to methods and compositions, i.e., pharmaceutical formulations, for treating and preventing diabetic foot ulcers. In a particular aspect, the disclosed methods and compositions pertain to water-based pharmaceutical formulations that are useful for administration in an aqueous foot bath. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

A device for irrigation of an oral cavity in a patient includes a suction element configured to be disposed in the oral cavity and configured to suction a fluid out of the oral cavity. The suction element also has one or more irrigation outlets configured to irrigate the oral cavity with the fluid. A suction line is fluidly coupled with the suction element and is configured to be fluidly coupled with a vacuum source. An irrigation line is fluidly coupled with the one or more irrigation outlets and is fluidly coupled with a source of the fluid.

An irrigation fluid dispensing tool well suited for use in a combination suction and irrigation tool has a frame carrying a surge flow pump formed of a flow controller of a manipulable handgrip of the tool handle, compressible irrigation fluid reservoir, and frame where the flow controller preferably is formed of a handle lever of the handgrip that is displaceable, preferably pivotable, between one or more of a surge flow actuation position, flow obstructing actuation position, and flow initiating position. The lever actuates a valve, preferably a pinch valve, when displaced toward the flow obstructing actuation position. The lever actuates the surge pump by compressing the reservoir, preferably squeeze bulb, against the frame when the handgrip is squeezed. The lever can be assembled to the frame in a protective shipping and storage position and is movable to a tool operating position providing irrigation fluid flow control during tool operation.