The present disclosure relates to an implantable drug delivery device including a manual control actuator that allows a patient to self-administer a fixed amount of a drug at a desired time. By controlling a drug level, the volume inside a drug chamber, the number of actuations, and the like, a device of the present disclosure allows a drug to be precisely controlled and delivered from the outside after the device is implanted in vivo, and thus it is convenient to control a drug administration schedule. Also, since a battery is not required, and internal control devices for electromagnetic control become unnecessary, it is more patient-friendly and economically feasible.

An autonomous drug delivery system advantageously utilizes physiological monitor outputs so as to automatically give a bolus of a rescue drug or other necessary medication when certain criteria and confidence levels are met. An emergency button is provided to manually trigger administration of the rescue drug. The rescue drug may be an opioid antagonist in response to an analgesia overdose, a hypotensive drug to avert an excessive drop in blood pressure or an anti-arrhythmia drug to suppress abnormal heartbeats, to name a few.