Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.

An apparatus including a hollow body, an inlet fluidly coupled to the hollow body, a piston slidably engaged within the hollow body, and a filter module arranged within the hollow body between the inlet and piston. The piston and hollow body cooperatively generate a negative pressure, relative to ambient, within the hollow body during distal piston translation from a first position to a second position, thereby drawing a fluid, such as blood, through the filter module into the hollow body. The piston and hollow body cooperatively generate a positive pressure, relative to ambient, within the hollow body during piston translation from the second position to the first position to egress the filtered fluid from the hollow body. The filter module may include a filter housing, a filter medium disposed within the housing, and a body valve configured to seal an open distal face of the filter housing.

A filter device (1) and a filtering infusion container comprising same. The filter device (1) comprises: a first component (20) comprising an outer casing (21) which is provided with a first accommodating cavity (213); a second component (40) comprising a flow channel (41); an actuator (50) used for closing or opening the flow channel (41), a head portion (51) of the actuator (50) being rotatably connected to the second component (40), a rod portion (52) of the actuator (50) being inserted in the flow channel (41), and covered by a seal cover (53); a filter membrane (30) sandwiched between the first component (20) and the second component (40); and a flow path (60) sequentially passing through the flow channel (41), the filter membrane (30), and the first accommodating cavity (213). The filtering infusion container comprises an infusion container (2) and the filter device (1). The filter device (1) is connected to the infusion container (2). One end of the flow path (60) leads to the infusion container (2), and the other end leads to the filter membrane (30). The structure of the filter device (1) enables the filter membrane (30) and an infusion fluid to be always located in different closed spaces before usage of the patient, so that the best integrity of the filter membrane (30) can be maintained; moreover, no fluid leakage will happen in the filter device (1), and the actuator (50) will not get loose during transportation.

An intravenous delivery system may have a liquid source containing a liquid, tubing, and an anti-run-dry membrane positioned such that the liquid, flowing form the liquid source to the tubing, passes through the anti-run-dry membrane. The anti-run-dry membrane may be positioned within an exterior wall of a drip unit, and may be secured to a seat of the exterior wall by an attachment component. The attachment component may have various forms, such as a secondary exterior wall that cooperates with the exterior wall to define a drip chamber, a washer positioned such that the anti-run-dry membrane is between the washer and the seat, and an adhesive ring formed of a pressure sensitive adhesive and secured to the anti-run-dry membrane and the seat via compression. Interference features may protrude inward from the exterior wall or outward from the anti-run-dry membrane to help keep the anti-run-dry membrane in place.

An apparatus including a hollow body, an inlet fluidly coupled to the hollow body, a piston slidably engaged within the hollow body, and a filter module arranged within the hollow body between the inlet and piston. The piston and hollow body cooperatively generate a negative pressure, relative to ambient, within the hollow body during distal piston translation from a first position to a second position, thereby drawing a fluid, such as blood, through the filter module into the hollow body. The piston and hollow body cooperatively generate a positive pressure, relative to ambient, within the hollow body during piston translation from the second position to the first position to egress the filtered fluid from the hollow body. The filter module may include a filter housing, a filter medium disposed within the housing, and a body valve configured to seal an open distal face of the filter housing.

An improved intravenous infusion set (10) to administer delivery of intravenous fluid to a patient, said intravenous infusion set (10) comprising: a drip chamber (12), a flexible infusion line (30) of sufficient length for fluid delivery to the patient and connected the drip chamber (12); a roller clamp (34) arranged movably along the length of the flexible infusion line (30), an air vent (18) with a cap arranged at the distal end (54) of the drip chamber (12) for management of air in the infusion system, said drip chamber (12) has a spike (14) on a distal end (54) and an infusion fluid outlet (20) at a proximal end (52) of the drip chamber (12), a fluid flow regulating member (36) sealed within the drip chamber (12) over said infusion fluid outlet (20) and wherein said infusion fluid outlet (20) configured to house a flow path adapter (22) which facilitates in administering continuous air free delivery of intravenous fluid to patients under gravitational pull.

The present disclosure provides a priming device, the priming device including: a housing having a proximal end and a distal end, the housing defining an axial direction extending substantially from the proximal end to the distal end; and a membrane disposed at the proximal end, wherein the housing defines a fluid communication channel extending substantially axially from an interior surface of the membrane towards the distal end and a filter disposed at the distal end of the housing, the filter being configured to allow a passage of air. In another aspect, there is provided a priming device having an adapter.

The present invention relates to a cassette module for controlling fluid flows, in particular for use in blood treatment systems or in infusion systems, wherein the cassette module comprises at least one base body having means for the flow guidance of at least one fluid flow and at least two membranes which are at least sectionally directly or indirectly in contact with the base body, wherein at least one actuation element is arranged between the membranes by means of which the means for the flow guidance can be acted on.

The present invention relates to a cassette module for controlling fluid flows, in particular for use in blood treatment systems or in infusion systems, wherein the cassette module has at least one first functional layer and at least one second functional layer, wherein the first functional layer has means for the flow guidance of at least one fluid flow, and wherein the cassette module furthermore has at least two membranes of which the first is in contact with the means for the flow guidance of a fluid flow, and wherein the second functional layer is arranged between the two membranes and has means for generating an underpressure between the membranes.

A filter for infusion medical lines including a flattened box-like body provided inside which is a plate-shaped element formed on whose one or both of the opposite faces are respective ribs defining inner channels. Arranged on the ribs are respective filtering hydrophilic membranes which separate the channels from respective interspaces delimited by a pair of half-shells. The interspaces are placed in communication with the inlet connector, the channels are placed in communication with the outlet fitting and the interspaces are placed in communication with the outside through vent openings arranged on the end walls of the box-like body.