An apparatus includes a housing, a carrier, a medicament container, and a flexible member. The housing defines an opening placing a gas chamber of the housing in fluid communication with an exterior volume. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container containing a medicament and includes an elastomeric member that seals the medicament therein. The flexible member has a distal end portion coupled to the elastomeric member and a proximal end portion coupled to a valve member. The flexible member transitions from a collapsed configuration to an expanded configuration when the elastomeric member moves within the medicament container. The flexible member moves the valve member relative to the opening when the flexible member transitions from the collapsed configuration to the expanded configuration.

A remote delivery device is provided which has media portholes in a sidewall, a tail piece attached to a rear end and a cannula attached to a front end. The body contains a plunger assembly which defines an injectable liquid chamber and a marking media chamber. The plunger assembly includes a front barbell plunger, rear barbell plunger and a plunger shaft with an O-Ring seated between the front and rear of said plunger shaft. The body also contains a single internal charge positioned behind the plunger assembly. When the charge is activated, the plunger assembly is thrust forwardly and dispenses an injectable liquid from the injectable liquid chamber through the cannula. Simultaneously, the plunger assembly also dispenses a marking media from the marking media chamber through marking media portholes. The provision of a single internal charge allows for a reduction in the length and weight of the device. The single internal charge provides evidence of successful injection of the injectable liquid when the media is displaced from the marking media chamber.

An injection device, for example, an auto-injector of any type, includes a sleeve configured to hold a medicament chamber. The sleeve may be sufficiently deformable such that it functions as a shock absorbing member to distribute the force exerted on the medicament chamber during use of the injection device.

An object of the present disclosure is at least to provide a technique for stimulating immunity in mammals, and the object is fulfilled by double-stranded RNA composed of: RNA composed of a base sequence represented by a sequence A below; and RNA composed of a base sequence represented by a sequence B below, each base of an (N).sub.13-25 portion in the base sequence represented by the sequence A and the base sequence represented by the sequence B being or not being complementary bases, and all of the bases of (N).sub.5-10 portions in the base sequence represented by the sequence A and the base sequence represented by the sequence B being complementary bases, and a Tm value of the (N).sub.5-10 portion being 20° C. or higher: Sequence A: 5′-UUGUCAUAUGGACAAGUCCAAGACU(N).sub.13-25(N).sub.5-10-3′ (SEQ ID No: 1), and Sequence B: 5′-(N).sub.5-10(N).sub.13-25AGUCUUGGACUUGUCCAUAUGACAA-3′ (SEQ ID No: 2).

Provided is a micro-jet drug injection device comprising: a pressure chamber having a pressure driving liquid hermetically filled therein; a drug chamber having a micro nozzle defined in a wall; an elastic membrane elastically expandable and restorable and to separate the pressure chamber from the drug chamber; an energy-focusing unit concentrating energy on the pressure driving liquid in the pressure chamber; and the storage unit supplying the drug solution therein into the drug chamber through a drug supply channel. The drug chamber has a partial inner space defined therein. The partial inner space is in fluid communication with the drug supply channel and is partially defined by the membrane. A nozzle closure is disposed inside or outside the drug chamber. The nozzle closure blocks inflow of air outside the micro-nozzle into the partial inner space after the elastic membrane has expanded and before elastic recovery of the membrane is completed.

A method for filling a container with a pyrotechnic charge using a filling system, said method including, when the powder is conveyed, a step of regulating the powder flow rate in which at least one powder conveyor device is brought to vibrate according to a vibration frequency control sequence, the vibration frequency being inversely proportional to the filling ratio of the container of the pyrotechnic charge.

A needleless injection device is provided that includes a body forming a housing, a gas generator, a tubular reservoir that contains an active ingredient, and a T-shaped elastically deformable membrane having a tubular portion. The reservoir extends axially in the housing from an upper end to a lower end and the tubular portion is configured to extend and lie axially in the reservoir under an effect of a pressure generated by the gas generator. An injection nozzle is arranged at the lower end of the reservoir. The tubular portion is funnel shaped and includes at least an upper segment that decreases along an axial elongation direction of the member and a lower segment that increases along the axial elongation direction. The axial length of the upper segment is greater than that of the lower segment.

Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

A jet injection system (10) comprising (i) a microfluidic device (100) for jet ejection and (ii) a laser-based heating system (200), wherein: —the microfluidic device (100) comprises a hosting chamber (110) defined by a chamber wall (120), the hosting chamber (110) having a chamber height he selected from the range of 5-400 μm, a chamber width we selected from the range of 2hc-10hc, and a chamber length l.sub.c defined by a first chamber end (111) and a second chamber end (112), wherein the second chamber end (112) comprises a first chamber opening (131) for jet ejection from the hosting chamber (110), and wherein the hosting chamber (110) is configured to host a liquid (50); —the laser-based heating system (200) is configured to provide laser radiation (201) to one or more of the chamber wall (120) and a liquid (50) in the hosting chamber (110).

A multistage gas-actuated drug supply device is connected to a drug injection container, the features include a gas supply unit, providing a gas; a plunger unit, composed of a plurality of hollow tubes, one end is connected to the gas supply unit, the hollow tubes can be stretched by the gas; a plunger top, connected to the other end of the plunger unit, pushing a medicament as the hollow tubes stretch; a gas chamber, penetrating the plunger unit, connected to the gas supply unit, holding the gas and stretching the hollow tubes as the gas increases, the gas chamber is further expanded; a limit part, located in the coupling end of the connected hollow tubes, limiting the collapsing length of the hollow tubes; and an airtight piece, located in the coupling end of the connected hollow tubes, sealing the gas chamber.