A medicament container holder for securing a medicament container having a generally tubular body arranged with a proximally directed neck portion and a flange portion arranged with a pierceable septum. The medicament container holder has mechanical holding elements that interact with the flange portion for preventing movement of the medicament container in a distal direction and having mechanical fixation elements configured to interact with the flange portion for urging the flange portion in the distal direction against the holding elements, where the medicament container holder has attachment elements for a medicament delivery member. The mechanical fixation elements are configured to engage with the medicament delivery member when attached to the attachment elements, such as to exert a force in the distal direction on said flange portion.

A two body syringe carrier assembly for use in an injection device is presented where a force dampener is operatively connected to the two bodies to dissipate spring force at the completion of the penetration and/or injection steps. The injection device has a generally elongated tubular housing, a syringe containing medicament and having a needle, a needle shield slidably arranged to the housing and protruding a distance outside the front end of the housing, a plunger arranged to act on the syringe and a pre-tensioned drive member arranged the drive the plunger.

An automatic injection device is provided, where the device includes a syringe carrier and a retraction assembly. The syringe carrier may include two identical parts that are discrete from one another and interlock with one another. Carrier includes a cushion to support the syringe. Protrusions may be provided on cushion to further support syringe. The retraction assembly includes a shuttle and a follower, the follower having a moveable latch. The follower has a coupled configuration in which the latch is biasedly coupled to the shuttle, and a decoupled configuration in which the latch is in sliding engagement with a curvilinear surface of the shuttle.

The present invention relates to a medicament container holder (10) comprising a body (12) adapted to receive a medicament container (14), the body (12) comprising proximally directed tongues (38) at its proximal end, engagement elements (42) arranged at the proximal end of the tongues (38), directed inwards, which engagement elements (42) are arranged to engage a neck portion (46) of the medicament container (14); wherein the tongues (38) deflect radially outwards when engaged by a needle shield (16) of said medicament container (14). The invention is characterised in that said tongues (38) with said engagement elements (42), engage with said neck portion (46) of said medicament container (14) for preventing the medicament container (14) from moving in a proximal direction relative the medicament container holder (10), when disengaged with said needle shield, wherein said tongues (38) are in a stressed state when in engagement with said neck portion (46).

Disclosed is an auto-injector for administering a medicament, comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper; a drive module coupled to move a plunger rod configured to move the first stopper; a resistance sensor configured to provide a resistance signal indicative of resistance against movement of the plunger rod; and a processing unit coupled to the drive module and to the resistance sensor. The processing unit being configured to: control the drive module to move the plunger rod towards the extended plunger rod position; determine present plunger rod position; receive the resistance signal; determine a cartridge parameter based on the resistance signal and the present plunger rod position; and control the drive module to adjust the movement of the plunger rod based on the cartridge parameter.

Provided is a manual drive unit for use with a cassette unit comprising a cassette unit housing containing there within a syringe comprising a barrel for containing a volume of a liquid drug formulation; a hollow needle at a front end of the barrel, the hollow needle defining a needle tip for dispensing of the liquid drug formulation; and a plunger that is axially movable within the barrel. The manual drive unit comprises a manual drive unit housing defining a docking cavity and a needle delivery aperture, wherein said docking cavity is arranged for docking receipt of the cassette unit at a docking position; and received by the manual drive unit housing and axially movable relative thereto, a manually operable drive transfer element for transferring axial drive to the plunger of the syringe for moving the plunger into the barrel of the syringe to eject at least part of the volume of liquid drug formulation.

The sheathed pharmaceutical cartridges described herein are resistant to structural damage such as burst and damage that can occur in and during activation of an auto-injector system. The cartridges having the protective sheath described herein are resistant to damaging forces generated in austere or demanding environments. In one embodiment, the glass cartridge can include a force absorption sheath to distribute and dissipate stress that extends from the outer surface of the body of the glass and positioned around at least a portion of the outer surface. In one embodiment, the recovered inner diameter of the sheath post-manufacture applies an inward compressive force on the body of glass.

The injection device includes a static structure including a first gear member. The injection device also includes a dynamic structure including a medicine container, a mechanism for pushing liquid medicine out of the medicine container for its injection to a patient, and a second gear member engaged with the first gear member. The injection device additionally includes a drive member for driving one of the first and second gear members so as to cause the dynamic structure to move relative to the static structure along a predetermined direction due to the engagement between the first and second gear members. The injection device further includes a clutch mechanism for maintaining engagement between the first and second gear members in normal condition of the injection device, and for allowing disengagement of the first and second gear members upon a shock received by the injection device along the predetermined direction.

Provided is a cassette unit suitable for use with an auto-injector having a drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity arranged for receipt of a syringe; a needle projection aperture; a needle cover defining a needle sheath for sheathing of a needle tip of the syringe; a removable cap that in a capping position fits over and thereby, acts such as to close off, the needle projection aperture, the removable cap defining a cap interior; provided to the removable cap, a cap insert; and provided to the cap insert, a connector defining one or more needle cover gripping elements for gripping the needle cover and the connector defines a central hub and the one or more needle gripper elements attach to the central hub and in spaced arrangement relative to each other, wherein the connector locates within the removable cap such that the central hub of the connector is in spaced relationship with a forward end wall or surface of the cap interior and the needle cover gripping elements project away from the forward end cap wall or surface of the cap interior and towards the open end of the cap, and wherein the removable cap is shaped to allow for limited axial travel of the cap insert there within.

A drug delivery device includes a housing having proximal and distal ends and a longitudinal axis extending therebetween, an injection assembly at least partially disposed within the housing including a needle or a cannula, a drive assembly operably coupled with the injection assembly, a shield slidably coupled with the housing and operably coupled with the drive assembly, and a retention mechanism. The drive assembly is engageable to deliver a medicament via the injection assembly. The shield is positionable in an extended position in which at least a proximal end extends a distance beyond the proximal end of the housing and a retracted position where the proximal end of the housing protrudes a distance beyond the proximal end of the shield. Moving the shield to the retracted position engages the drive assembly to deliver the medicament via the injection assembly. The retention mechanism limits movement of the drive assembly to restrict engagement thereof such that the drive assembly is restricted from delivering the medicament via the injection assembly.