A syringe of a syringe assembly is provided with a body portion capable of being filled with a drug solution and a female port nozzle portion which extends from a distal end of the body portion and includes a communication port on a proximal end of the female port nozzle. The body portion includes a distal end wall surface and a side wall surface to which a liquid lubricant is applied. The distal end wall surface includes a concave portion arranged radially outside an inner edge portion adjacent to the communication port and concave in a distal end direction more than at least a part of the inner edge portion, and the concave portion is arranged to fully surround the communication port and may store the liquid lubricant.

A precision syringe includes a syringe barrel and plunger that has a base, an internal portion, and an external portion. The internal portion of the plunger extends longitudinally into the syringe barrel. The internal portion has a first end coupled to the base and a second end that is configured to push fluid out of and/or suction fluid into the syringe barrel. The external portion extends longitudinally along an outer surface of the syringe barrel. The external portion has a first end coupled to the base and a second end that is configured to receive an applied force that causes the plunger to move relative to the syringe barrel so that the second end of the internal portion is actuated through a portion of the syringe barrel (e.g., to dispense fluid from or suction fluid into the syringe barrel).

The invention discloses a sterile syringe (100) comprising a barrel (1) having internal surfaces (2), a plunger (3) movable within the barrel, a non-sliding seal (7) between the barrel and the plunger defining a sealed volume (8) and at least one filter (9) allowing only filtered gases to enter the sealed volume such that the syringe maintains its sterility even after several uses. The filters could be positioned on different locations on the syringe like on the non-sliding seal, the barrel, the barrel flange or the plunger handle.

An embodiment of the present invention is an encased syringe in which a prefilled syringe is accommodated in a case. The prefilled syringe includes a cylindrical syringe body filled with a foamable material and a plunger pressed into the syringe body on one end side. The case includes a body accommodating part faulted to be depressed along the shape of the syringe body to accommodate the syringe body and a plunger accommodating part formed to be depressed along the shape of the plunger to accommodate the plunger. The length of the plunger accommodating part is smaller than the length of the plunger in an axial direction of the prefilled syringe.

This disclosure provides a guiding device shaped so as to hold a syringe equipped with a harvesting cannula and to allow to insert the harvesting cannula at the exact depth below the skin of the patient to attain the subcutaneous adipose tissue. The cannula may be moved move back and forth in a driven manner immersed in the subcutaneous adipose tissue without any risk of wounding inner organs of the patient and in the proper layer. This disclosure provides also a syringe holder in the form of a hollow box with circular openings on a top surface. The circular openings are shaped so as to let a barrel of a syringe enter therein and a barrel flange not pass therethrough, in order to keep harvesting syringes hung with their barrel flanges abutted against the top surface of the syringe holder and their barrels protected into the hollow box.

Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper. The stopper has a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition. The stopper has a circumferential surface partially contacting an inner surface of the barrel. A surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness.

A device configured to delivery medication is disclosed. The device contains a plurality of sensors, including a magnetic proximity sensor and a temperature sensor. The proximity magnetic sensor can detect whether all the medication has been injected into a patient. The temperature sensor can ascertain whether the temperature of the medication has reached a predetermined or proper level for injection. The device also contains a locking device that can lock the device when the temperature of the medication is below this proper temperature and can automatically unlock the device when the temperature reaches or exceeds this proper temperature.

A device and method for aspirating graft tissue and delivering the graft tissue to a target delivery site (for example, when performing Descemet's membrane endothelial keratoplasty). In one embodiment, an injector comprises a cylinder and a plunger at least partially located within the cylinder, the plunger being rotatably advanceable and retractable within the cylinder. In one aspect of the embodiment, rotating the plunger in a first direction within the cylinder controllably aspirates a graft tissue into the injector and rotating the plunger in a second direction opposite the first direction controllably ejects the graft tissue from the injector.