A device and system for treatment of tissue by direct application thereto of therapeutic substances in the form of a stream of therapeutic droplets carried in a high velocity gas. The high velocity gas is produced by accelerating a flow of gas through at least one gas discharge nozzle. At least one flow of therapeutic substance is introduced into the high velocity gas through at least one liquid discharge nozzle, thereby fragmenting the at least one flow of therapeutic liquid into a stream of therapeutic droplets. The stream is accelerated to a velocity similar to the velocity of the gas discharge flow. The accelerated therapeutic droplet stream is then applied to a tissue for therapeutic treatment. The device and system contain a gas stream shield generator that provides a shield which prevents rebounding and dispersing droplets produced after impinging on the tissue from travelling in the direction of a user.

Disclosed herein is a device for administering a liquid therapeutic substance to tissue, including a housing having a liquid inlet port a gas inlet port connected to a pressurized gas source; at least one therapeutic substance supply assembly mounted onto said housing, each therapeutic substance supply assembly including at least one syringe dispenser connector configured for receiving a syringe dispenser containing a predefined quantity or concentration of the liquid therapeutic substance, each syringe dispenser in fluid flow communication with one of at least one valve projecting from and external to said assembly, said syringe dispenser includes a container configured to store the liquid therapeutic substance and a piston configured to be pulled into the container as the liquid therapeutic substance is removed from said container under suction so as to flow through said at least one valve.

A disinfection tip is described for disinfecting a threaded connector of a syringe. The disinfection tip includes a cylindrical outer housing, a substantially cylindrical inner housing extending from a distal wall of the outer housing, a distal chamber defined by the outer sidewall of the inner housing, the inner wall of the outer housing and the distal wall of the outer housing, the distal chamber being in fluid communication with the cavity, the distal chamber retaining a disinfectant or antimicrobial agent when the disinfection tip is disposed within an outer wall of the luer connector of the syringe and, at least one jet orifice radially disposed on the inner rim in fluid communication with the distal chamber allowing for fluid to pass from the distal chamber through the jet orifice directing the disinfectant or antimicrobial agent towards a center of the outer housing when the disinfection tip is further inserted into the luer connector of the syringe, the insertion of the disinfection tip causing the volume of the distal chamber to reduce and expel disinfectant or antimicrobial agent through the at least one jet orifice.

A drug solution administration method using an inkjet device including an inkjet head that ejects a drug solution, and a controller that controls the ejection of the drug solution from the inkjet head, wherein the drug solution is made to pierce a target site and is administered to the target site by ejecting the drug solution from the inkjet head so that a diameter of the drug solution when it is ejected from the inkjet head is 20 μm or more and 200 μm or less and an ejection rate of the drug solution when it is ejected from the inkjet head is 30 m/s or more under control of the controller.

Nocilytic devices and methods for treatment of dyspareunia are provided. In particular, a device is provided, which inserts intravaginally with inflatable balloons to map the location of pain during application of force exerted against/on the luminal side of the vaginal wall and/or vulva of a human patient, or sensors to detect locations for application of nocilytic therapy.

An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

A disinfection tip is described for disinfecting a threaded connector of a syringe. The disinfection tip includes a cylindrical outer housing, a substantially cylindrical inner housing extending from a distal wall of the outer housing, a distal chamber defined by the outer sidewall of the inner housing, the inner wall of the outer housing and the distal wall of the outer housing, the distal chamber being in fluid communication with the cavity, the distal chamber retaining a disinfectant or antimicrobial agent when the disinfection tip is disposed within an outer wall of the luer connector of the syringe and, at least one jet orifice radially disposed on the inner rim in fluid communication with the distal chamber allowing for fluid to pass from the distal chamber through the jet orifice directing the disinfectant or antimicrobial agent towards a center of the outer housing when the disinfection tip is further inserted into the luer connector of the syringe, the insertion of the disinfection tip causing the volume of the distal chamber to reduce and expel disinfectant or antimicrobial agent through the at least one jet orifice.

Disclosed herein is a dental anesthetic delivery device. The dental anesthetic delivery device may comprise a handle and a body having a trough with a concave, horseshoe-shaped inner cavity. The inner cavity, which may be positioned over and around the area of a painful tooth, may further provide a soft or otherwise non-irritating interior surface which may comprise materials such as mesh, gauze, padding, or similar. The interior surface may act as a carrier of and delivery platform for various dental anesthetic substances. The dental anesthetic delivery device may incorporate a temperature modulation system that allows for the delivery of heat or cold to the affected area.

An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.