The present disclosure is directed towards a needleless injection device that includes a body, a gas generator, an injection system that extends axially along an injection axis and includes at least one plunger, an active ingredient reservoir, an injection nozzle that delimits at least one injection channel, a cover that houses the body of the device, a removable cap that protects a lower downstream end of the injection nozzle, a stopper that houses the cap, and a blocking element. The stopper is pivotally mounted about the injection axis between a closed position in which the stopper is locked on the injection device and an open position in which the stopper is unlocked from the injection device. The blocking element is radially interposed between the cap and the stopper, and is configured to block, by friction, the relative pivoting of the cap and of the stopper, about the injection axis.

An injection guide globally aligns an injector to an angle selected for consistent subcutaneous delivery of an injectate, while locally aligning a patient's skin normal to the injection path at the location where the injection pierces the skin. This arrangement advantageously maintains controlled contact between an injector and a subject's skin in order to deliver the full, intended volume of injectate into the patient's subcutaneous layer while avoiding misdelivery into adjacent layers such as the patient's dermis or muscle.

A free-jet dosing system for administering a fluid into or under the skin having a micropump and a nozzle arranged on the outlet side. The micropump has an inlet and an outlet and is configured to transport a fluid from the inlet to the outlet and to generate a blocking pressure of at least 20 bar at the outlet. The nozzle is configured to output the fluid output at the outlet as a free jet at a fluid pressure so that the fluid of the free jet may be injected into the skin.

An instrument with a first conduit for emitting a first fluid from a first opening of the first conduit in an axial direction into a reacceleration zone and with a second conduit for channeling of a second fluid in the reacceleration zone in axial direction is provided such that active ingredient components, e.g. cells, of the second fluid are reaccelerated in axial direction as a result of the flow in the reacceleration zone by means of the first fluid that enters the reacceleration zone. A coaxial configuration of the first and the second conduit is preferred, because in doing so, around the first opening a shell jet of second fluid can be created that flows downstream in axial direction around the central working jet. In addition, a head for an inventive instrument and an application system with an inventive instrument is provided.

A device for repetitive needleless injection including a handheld unit having at least a cell fillable with a liquid, and a propulsion mechanism to apply a sequence of pressure pulses to the liquid to eject a micro-jet of the liquid from the cell via an orifice with a velocity that is sufficient to enable the micro-jet to penetrate into the surface; a reservoir that is connected to the cell by a conduit to enable the liquid to flow from the reservoir to the cell; a controller that is configured to operate the propulsion mechanism repeatedly; and a unidirectional valve to enable flow of the liquid from the reservoir to the cell and to prevent backflow. The propulsion mechanism includes an impulse generator configured to displace an actuation surface to generate the pulse; a plunger to transmit the pulse to the cell, and a restoration mechanism to retract the plunger.

The present application relates to a hydraulic assembly of a generator of medium-pressure and high-pressure pulsed or non-pulsed jets. The hydraulic assembly includes a hydraulic pipe with a flexible deformable zone. The flexible deformable zone can have a state of rest and a shut-off state. The hydraulic assembly includes a unit configured to hold the hydraulic pipe with a first clamp and a second clamp holding the hydraulic pipe on each side of the flexible deformable zone. The unit can form an open space between the first clamp and the second clamp.

This disclosure relates to dental anesthetic delivery devices and associated methods for using the same. In certain embodiments, an anesthetic delivery device may comprise a pressure-driven needleless injector configured to deliver anesthetic deeply into the gingiva, allowing for a deep numbing and anesthetic effect and reducing pain from subsequent anesthetic injections and/or dental procedures. In some embodiments, the anesthetic delivery device may be T-shaped allowing for a shorter longitude axis length of the syringe body, improved clinician view of the oral cavity during use, single hand and/or ambidextrous use, and/or improved control during positioning.

The invention proposes a method and a device for needleless injection of liquid into a substrate, in particular of a liquid pharmaceutical or cosmetic preparation into a biological tissue, which allows a particularly fine liquid jet to be reliably injected completely into the substrate in a particularly advantageous manner. According to the invention, this is achieved by setting the ejected liquid jet in rotation about its jet axis before its impingement on the substrate, so that the jet receives a rotational movement and thus practically drills into the substrate without splashing away laterally.

The application discloses a multi-chamber, multi-formulation fluid delivery system, comprising a multi-chamber applicator in fluid communication with multi-chamber packaging. Applicators according to the instant disclosure have reduced squeeze-strength requirements, and are useful for dispensing fluids, including medicaments, to animals, including livestock animals. The multi-chamber packaging provides separate storage for formulations containing incompatible active ingredients, and is suitable for use with the multi-chamber applicator. The application also discloses methods for using the system to simultaneously deliver multiple active ingredients, at least some of which are not suitable for co-formulation, thus reducing the time, economic burden and animal stress involved with applying multiple, separate formulations to animals.

An apparatus for use in injectate delivery includes an actuator including a linkage, a force generating mechanism mechanically coupled to the linkage, and a controller coupled to the force generating mechanism. The force generating mechanism includes a passive force generator and an active force generator. In operation and on the basis of a control signal, the controller is configured to control the force generating mechanism to provide an input force to the linkage that is a combination of the first force provided by the passive force generator and a second force provided by the active force generator.