The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the particles, a cassette housing, and a cassette membrane. The cassette housing can comprise an Ethylene Vinyl Acetate (EVA) copolymer of 18% to 28% by weight of Vinyl Acetate (VA). The device can also include a safety interlock to prevent or minimize the risk that the device will be unintentionally activated. The device can also have a silencer.

Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

A device for delivery of particles into biological tissue includes at least one conduit and a propellant source configured to release a propellant into the conduit. A source of first particles is configured to release first particles into the conduit. A source of second particles is configured to release second particles into the conduit. The second particles comprise a functional material intended to interact with the biological tissue and having a density less than a density of the first particles. The propellant source and the conduit are configured to propel the particles in a collimated stream toward the biological tissue. The first particles are configured to penetrate the biological tissue to create micropores that increase porosity of the biological tissue and the second particles configured to enter the porous biological tissue.

A device for delivery of particles into biological tissue includes at least one conduit and a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit. A particle source is configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w. The propellant source and the conduit are configured to propel the elongated particles in a collimated particle stream toward the biological tissue. An alignment mechanism is configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit. The aligned elongated particles are ejected from the conduit and impact the biological tissue.

The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

A syringe includes a holding portion that accommodates an injection objective substance, a driving portion that applies injection energy, and a nozzle portion that includes a passage for injection, with these portions being loaded into a housing independently, whereby a state where the injection objective substance can be injected is established. The syringe includes a regulating means for regulating a loading position of the holding portion and the driving portion within the housing so that a loading state, where the holding portion and the driving portion are always loaded in the same order into the housing, is established for injection of the injection objective substance. Due to this, it is possible to facilitate injection of injection liquid ideal for various purposes and to improve user's convenience.

The invention relates to a needleless injection device or a device for the needleless injection of a substance into a tissue or body, with which device a substance, in particular an active substance, can be injected by means of high pressure. A device according to the invention comprises a chamber (11) containing a pyrotechnic material, wherein the chamber has a fixed double membrane (13, 15) at a discharge opening, wherein the skin-side membrane (15) of the double membrane (13, 15) is provided with a substance application (25).

A successful injection lies in the fact that sufficient substance is introduced into the body through the tissue barrier or body barrier, in particular such as the skin.

A syringe includes a holding portion that accommodates an injection objective substance, a driving portion that applies injection energy, and a nozzle portion that includes a passage for injection, with these portions being loaded into a housing independently, whereby a state where the injection objective substance can be injected is established. The syringe includes a regulating means for regulating a loading position of the holding portion and the driving portion within the housing so that a loading state, where the holding portion and the driving portion are always loaded in the same order into the housing, is established for injection of the injection objective substance. Due to this, it is possible to facilitate injection of injection liquid ideal for various purposes and to improve user's convenience.

An injection device for use with a cartridge facilities a transfer of fluid from the cartridge into an injection bore.